• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Mediators of inflammation >Inhibition of Osteodast Generation:A Novel Function of the Bone Morphogenetic Protein 7/Osteogenic Protein 1
【24h】

Inhibition of Osteodast Generation:A Novel Function of the Bone Morphogenetic Protein 7/Osteogenic Protein 1

机译：抑制骨质淋摩司生成：骨形态发生蛋白7 /骨质发生蛋白1的新功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Monocytes have the potential to differentiate to either macrophages, dendritic cells, or to osteoclasts. The microenvironment, particularly cytokines, directs the monocyte differentiation. Receptors of NFkB (RANK) ligand, tumor necrosis factor (TNF) alpha, or interleukin- (IL-) 8 have be identified as inducers of osteoclastogenesis, whereas others, such as IL-10 or transforming growth factor (TGF)fi inhibit osteoclast generation or induce differentiation towards a dendritic cell type. We now describe that bone morphogenetic protein (BMP) 7/osteogenic protein- (OP-) 1 inhibited the differentiation of human CD14+ monocytes to osteoclasts. In the presence of BMP7/OP-1 the transcription factors c-Fos and NFATcl, though upregulated and translocated to the nucleus in response to either RANKL or IL-8, did not persist. In parallel, MafB, a transcription factor expressed by monocytes and required for differentiation to macrophages but inhibiting osteoclast generation, was preserved. Because both persistence of NFATcl and downregulation of MafB are crucial for osteoclastogenesis, we conclude that BMP7/OP-1 inhibits the generation of osteoclasts by interfering with signalling pathways.
机译：单核细胞有可能分化为巨噬细胞，树突细胞或疏松骨硬质体。微环境，特别是细胞因子引导单核细胞分化。 NFKB（秩）配体，肿瘤坏死因子（TNF）α或白细胞介素 - （IL-）8的受体已被鉴定为骨酸核细胞发生的诱导剂，而其他，例如IL-10或转化生长因子（TGF）抑制疏松骨质体产生或诱导朝向树突细胞类型的分化。我们现在描述骨形态发生蛋白（BMP）7 / osteogenic蛋白 - （OP-）1抑制人CD14 +单核细胞的分化为骨酸细胞。在BMP7 / OP-1存在下，转录因子C-FOS和NFATCL，虽然响应于RANKL或IL-8而上调并向核转移而不持续存在。并行，MAFB，由单核细胞表达的转录因子，并抑制巨噬细胞所需的分化但抑制破骨细胞产生。因为NFATCL的持续性和MAFB的下调对于骨核细胞发生至关重要，我们得出结论，BMP7 / OP-1通过干扰信号通路来抑制疏松骨硬质体的产生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号