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IL-8, IL-10, TGF-beta, and GCSF Levels Were Increased in Severe Persistent Allergic Asthma Patients with the Anti-IgE Treatment

机译：IL-8，IL-10，TGF-Beta和GCSF水平在抗IgE治疗的严重持续过敏性过敏性哮喘患者中增加

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Background. Allergic asthma is showed an increase in Th2-cytokine and IgE levels and an accumulation activation of Th2 cells, eosinophils and mast cells. However, recent studies focused on cell-based mechanisms for the pathogenesis of allergic asthma. Objectives. In this study, we compare the anti-IgE treatment modality in the dynamics of immune system cytokine levels in severe persistent asthma (SPA) patients who had no other any allergic disease, newly diagnosed allergic asthma patients and healthy volunteers. Study Design. The study population consisted of 14 SPA patients, 14 newly diagnosed allergic asthma patients and 14 healthy volunteers included as controls. Cytokine levels were measured. Total and specific IgE levels of anti-IgE monoclonal antibody treated patients, serum high-sensitivity C-reactive protein (hsCRP) levels, FEV1/FVC rates and asthma control test (ACT) were measured for the clinical follow-up. Results. We observed that SPA patients presented increasing levels of IL-8, IL-10, TGF-beta and GCSF during the anti-IgE treatment in period of sampling times at 4 months and 18 months. However this increase was not correlated neither with serum hsCRP levels nor FEV1/FVC rates. Conclusions. Our study gives a different perspective for the SPA and anti-IgE immunotherapy efficacy at the cell cytokine-linked step.
机译：背景。过敏性哮喘显示Th2-细胞因子和IgE水平的增加以及TH2细胞，嗜酸性粒细胞和肥大细胞的累积活化。然而，最近的研究侧重于基于细胞的哮喘发病机制的机制。目标。在这项研究中，我们在严重持续哮喘（SPA）患者中的免疫系统细胞因子水平的动态中的抗IGE治疗方式进行了比较，该哮喘患者没有其他任何过敏性疾病，新诊断过敏的哮喘患者和健康志愿者。学习规划。研究人群由14名SPA患者组成，14名新诊断的过敏性哮喘患者和14名健康志愿者作为对照。测量细胞因子水平。测量临床随访的抗IgE单克隆抗体治疗患者的总和特异性的抗IgE单克隆抗体治疗患者，血清高灵敏度C反应蛋白（HSCRP）水平，FEV1 / FVC速率和哮喘控制试验（ACT）。结果。我们观察到SPA患者在4个月和18个月的采样时间内抗IgE治疗期间呈现出IL-8，IL-10，TGF-Beta和GCSF的水平增加。然而，这种增加既不与血清HSCRP水平和FEV1 / FVC速率都不相关。结论。我们的研究在细胞细胞因子连接步骤中给出了SPA和抗IGE免疫治疗疗效的不同视角。

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