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首页> 外文期刊>Medycyna Weterynaryjna >Canine oral cavity T-cell lymphoma - histopathological and immunohistochemical study
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Canine oral cavity T-cell lymphoma - histopathological and immunohistochemical study

机译：犬口腔腔T细胞淋巴瘤 - 组织病理学和免疫组化研究

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摘要

This study presents a case of an unusually located canine T-cell lymphoma. A 5-year-old female dachshund was presented with a tumour located in the buccal mucosa. The tumour was excised, fixed, processed routinely for histopathology and stained. Microscopically, a dense infiltration of round cells with scant cytoplasm, large nuclei and numerous mitotic figures was detected within the mucosa. The tumour was diagnosed as a round-cell tumour. Subsequently, additional tumours developed in the mandibular and hock joint areas. The primary tumour was stained immunohistochemically using an antibody panel (CD3, MHCII, mast cell tryptase, CD18, CD79a). The tumour cells showed variable cytoplasmic expression of CD3, moderate-to-strong cytoplasmic or membranous expression of MHCII, and they were mast cell tryptase, CD18 and CD79a negative. The final diagnosis was T-cell lymphoma. The dog passed away within the next two months. This study revealed, that immunohistochemistry is necessary to diagnose canine oral cavity round cell tumours.
机译：本研究提出了异常定位的犬T细胞淋巴瘤的情况。一个5岁的女性腊肠犬被患有位于口腔粘膜的肿瘤。切除肿瘤，固定，常规处理组织病理学并染色。微观地，在粘膜内检测到具有瘢痕细胞质，大核和许多有丝分裂图的圆形细胞的致密浸润。肿瘤被诊断为圆细胞肿瘤。随后，在下颌骨和Hock接合区域中产生的额外肿瘤。使用抗体面板（CD3，MHCII，肥大细胞胰蛋白酶，CD18，CD79a）免疫肿瘤染色免疫组织化学。肿瘤细胞显示CD3，中等至强细胞质或MHCII的中等至强细胞质或膜表达的可变细胞质表达，它们是肥大细胞胰蛋白酶，CD18和CD79a阴性。最终诊断是T细胞淋巴瘤。狗在接下来的两个月内逝世了。本研究显示，免疫组织化学是诊断犬口腔圆形细胞瘤的必要条件。

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