...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Medycyna Weterynaryjna >Effect of xylazine, medetomidine and dexmedetomidine on cardiac conduction in pigs
【24h】

Effect of xylazine, medetomidine and dexmedetomidine on cardiac conduction in pigs

机译：甲嗪，枸杞和右甲甲基咪腺嘌呤对猪心脏传导的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The majority of anaesthetics used in studies regarding heart arrhythmias may affect the cardiac conduction system, thus influencing the results. In veterinary medicine, xylazine, medetomidine and dexmedetomidine are commonly used for premedication in laboratory and companion animals. To date, there have been no studies assessing the effect of these substances on the cardiac conduction system. The aim of this study was to assess the effect of xylazine, medetomidine and dexmedetomidine on the parameters of the cardiac conduction system in pigs. The study was carried out on 18 Great White Polish male pigs weighing from 21 to 40 kg. The animals were divided into three equal groups. The animals from the first group received xylazine at a dose of 2 mg/kg i.v.; those from the second group received medetomidine at 40 mcg/kg i.v.; and those from the third group received dexmedetomidine at 10 mcg/kg i.v. The electrophysiological activity of the heart was analysed using an invasive electrophysiological study (EPS). During the EPS, a decrease in the heart rate after substance administration was observed in all animals, but there were no statistically significant differences in the cardiac conduction parameters. A pro-arrhythmic effect of xylazine was observed, but no statistically significant changes in the EPS parameters were noted. Our results indicate that medetomidine and dexmedetomidine may be used as standard premedication drugs in electrophysiological studies in pigs. Their use may facilitate animal preparation procedures without affecting study results.
机译：关于心律失常的研究中使用的大多数麻醉剂可能会影响心脏传导系统，从而影响结果。在兽医中，甲嗪，麦妥咪唑和德克梅哌咪唑常用于实验室和伴侣动物中的预生。迄今为止，没有研究评估这些物质对心脏传导系统的影响。本研究的目的是评估木嗪，梅特咪唑和右甲酰上致咪啶的作用对猪心脏传导系统的参数。这项研究于18名伟大的白色抛光雄性猪，其重量为21至40千克。将动物分成三个相等的组。来自第一组的动物以2mg / kg i.v的剂量接受甲嗪。来自第二组的那些，在40 mcg / kg i.v中接受了Mebetomidine;来自第三组的那些在10 mcg / kg i.v中获得右甲酰过嘌呤。使用侵入式电生理学研究（EPS）分析了心脏的电生理活性。在EPS期间，在所有动物中观察到物质给药后心率的降低，但心脏传导参数没有统计学上显着的差异。观察到番茄嗪的促疗法，但注意到EPS参数中没有统计学上显着的变化。我们的研究结果表明，Mebetomidine和Dexmedetomidine可以用作猪电生理学研究中的标准遗传药物。他们的使用可能促进动物的制备程序而不影响研究结果。

著录项

  • 来源
    《Medycyna Weterynaryjna》 |2018年第3期|共6页
  • 作者

    Cepiel Alicja; Noszczyk-Nowak Agnieszka; Janiszewski Adrian; Paslawski Robert; Paslawska Urszula;

  • 作者单位

    Wroclaw Univ Environm &

    Life Sci Clin Dis Horses Dogs &

    Cats Dept Internal Dis Fac Vet Med Pl Grunwaldzki 47 PL-50366 Wroclaw Poland;

    Wroclaw Univ Environm &

    Life Sci Clin Dis Horses Dogs &

    Cats Dept Internal Dis Fac Vet Med Pl Grunwaldzki 47 PL-50366 Wroclaw Poland;

    Wroclaw Univ Environm &

    Life Sci Ctr Expt Diagnost &

    Biomed Innovat Fac Vet Med Pl Grunwaldzki 47 PL-50366 Wroclaw Poland;

    Wroclaw Med Univ Dept &

    Clin Internal &

    Occupat Dis &

    Hypertens Ul Borowska 213 PL-50556 Wroclaw Poland;

    Wroclaw Univ Environm &

    Life Sci Clin Dis Horses Dogs &

    Cats Dept Internal Dis Fac Vet Med Pl Grunwaldzki 47 PL-50366 Wroclaw Poland;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物医学（兽医学）;
  • 关键词

    xylazine; medetomidine; dexmedetomidine; EPS; pigs;

    机译：甲嗪;medetomidine;dexmedetomidine;eps;猪;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号