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首页> 外文期刊>Melanoma research >Intracorneal pustular drug eruption, a novel cutaneous adverse event in anti-programmed cell death-1 patients that highlights the effect of anti-programmed cell death-1 in neutrophils
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Intracorneal pustular drug eruption, a novel cutaneous adverse event in anti-programmed cell death-1 patients that highlights the effect of anti-programmed cell death-1 in neutrophils

机译：脑内脓疱药物喷发，一种新型皮肤不良事件在反编程的细胞死亡-1患者中，突出了中性粒细胞的反编程细胞死亡-1的效果

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摘要

The introduction of anti-programmed cell death-1 (anti-PD1) monoclonal antibodies has revolutionized the treatment of various advanced malignancies. Despite its efficacy, anti-PD1 therapy is accompanied by a variety of cutaneous adverse events. A 79-year-old man developed erythematous scaly plaques and pustules of the forehead, legs and arms after four cycles of nivolumab infusions every 2 weeks. Histology showed intracorneal pustules with dermal neutrophils and eosinophils. He was treated successfully with topical corticosteroids without discontinuation of nivolumab. We report subcorneal pustular eruption as a novel cutaneous adverse event in patients on anti-PD1 therapy. Other neutrophilic eruptions (psoriasis, Sweet's syndrome, acute generalized pustulosis) have been reported in patients on anti-PD1 treatments, suggesting the neutrophil as another cell type modulated by anti-PD1 antibodies. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
机译：引入抗程序化细胞死亡-1（抗PD1）单克隆抗体已经彻底改变了各种晚期恶性肿瘤的治疗。 尽管有效，但抗PD1疗法伴有各种皮肤不良事件。 一名79岁的男子发育了每2周每2周4个患者的4个循环后额头，腿部和臂的鳞片状斑块和脓疱。 组织学显示具有皮肤嗜中性粒细胞和嗜酸性粒细胞的脑内脓疱。 他被局部皮质类固醇成功待遇，而不会停止幼血管。 我们向抗PD1疗法患者的一种新型皮肤不良事件报告了亚科群脓疱爆发。 在抗PD1治疗的患者中报道了其他中性嗜嗜中性灭火（牛皮癣，甜蜜的综合征，急性广义猪症），表明中性粒细胞作为通过抗PD1抗体调节的另一种细胞类型。 版权所有（C）2017 Wolters Kluwer Health，Inc。保留所有权利。

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