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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >A comparison of fetal behaviour in term fetuses exposed to anticonvulsant medication with unexposed controls.
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A comparison of fetal behaviour in term fetuses exposed to anticonvulsant medication with unexposed controls.

机译：接触抗惊厥药物的足月胎儿与未接触对照组的胎儿行为比较。

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OBJECTIVE: To compare behaviour in term fetuses exposed to anticonvulsants with unexposed controls. DESIGN: An observational study. SETTING: Pregnancy Assessment Centre, University Hospital, Nottingham, UK. SAMPLE: Seventeen fetuses whose mothers were taking anticonvulsants and 94 fetuses whose mothers were on no medication between 28 and 41 weeks. METHODS: Behaviour (fetal heart rate and activity) was recorded with the use of Doppler ultrasound. The duration of recording was 60 minutes or more in all but four recordings (minimum 49 minutes). MAIN OUTCOME MEASURES: Behavioural criteria studied were: 1. the relative percentage time spent in low and high variation fetal heart rate patterns; 2. the duration and recurrence of fetal activity; 3. the number of accelerations in low and high fetal heart rate variation; and 4. the number of fetal behavioural state transitions. RESULTS: The two groups were comparable in terms of maternal age, parity. birthweight, Apgar scores and absence of neonatal problems. There was less fetal activity in the anticonvulsant group, but this was only statistically significant at 33-36 weeks in fetal heart rate pattern B (equivalent to state 2F). CONCLUSIONS: This study showed that fetuses exposed to anticonvulsant medication exhibited a trend of being less active. There were no other significant differences in behaviour. The data do not support the hypothesis of substantial differences in behaviour in fetuses exposed to anticonvulsants.
机译：目的：比较暴露于抗惊厥药的足月胎儿与未暴露对照的行为。设计：一项观察性研究。地点：英国诺丁汉大学医院妊娠评估中心。样品：母亲在服用抗惊厥药的胎儿有17例，母亲在28周至41周内未服药的有94例。方法：使用多普勒超声记录行为（胎儿心率和活动）。除四次录音外，所有录音的持续时间均为60分钟或更长（最少49分钟）。主要观察指标：研究的行为标准是：1.低胎心率和高胎心率模式花费的相对时间百分比; 2.胎儿活动的持续时间和复发; 3.胎心率高低变化的加速次数; 4.胎儿行为状态转变的次数。结果：两组在产妇年龄，均等方面具有可比性。出生体重，Apgar评分和无新生儿问题。抗惊厥组的胎儿活动较少，但在胎心率模式B（相当于状态2F）中只有33-36周才具有统计学意义。结论：这项研究表明，接受抗惊厥药物治疗的胎儿表现出活动减少的趋势。行为上没有其他显着差异。该数据不支持在暴露于抗惊厥剂的胎儿行为上存在实质性差异的假设。

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