...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >WEE1 inhibition and genomic instability in cancer
【24h】

WEE1 inhibition and genomic instability in cancer

机译：WEE1抑制和基因组不稳定

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One of the hallmarks of cancer is genomic instability controlled by cell cycle checkpoints. The G1 and G2 checkpoints allow DNA damage responses, whereas the mitotic checkpoint enables correct seggregation of the sister chromosomes to prevent aneuploidy. Cancer cells often lack a functional G1 arrest and rely on G2 arrest for DNA damage responses. WEE1 kinase is an important regulator of the G2 checkpoint and is overexpressed in various cancer types. Inhibition of WEE1 is a promising strategy in cancer therapy in combination with DNA-damaging agents, especially when cancer cells harbor p53 mutations, as it causes mitotic catastrophy when DNA is not repaired during G2 arrest. Cancer cell response to WEE1 inhibition monotherapy has also been demonstrated in various types of cancer, including p53 wild-type cancers. We postulate that chromosomal instability can explain tumor response to WEE1 monotherapy. Therefore, chromosomal instability may need to be taken into account when determining the most effective strategy for the use of WEE1 inhibitors in cancer therapy.
机译：癌症的标志之一是由细胞周期检查点控制的基因组不稳定性。 G1和G2检查点可实现DNA损伤反应，而有丝分裂检查点可正确区分姐妹染色体，以防止非整倍性。癌细胞通常缺乏功能性的G1阻滞，而依赖于G2阻滞来进行DNA损伤反应。 WEE1激酶是G2检查点的重要调节剂，在多种癌症类型中过表达。 WEE1的抑制是与DNA破坏剂联合用于癌症治疗的一种有前途的策略，尤其是当癌细胞带有p53突变时，因为在G2阻滞期间未修复DNA时会引起有丝分裂性营养不良。癌细胞对WEE1抑制单一疗法的反应也已在多种类型的癌症中得到证实，包括p53野生型癌症。我们假设染色体不稳定可以解释肿瘤对WEE1单药治疗的反应。因此，在确定在癌症治疗中使用WEE1抑制剂的最有效策略时，可能需要考虑染色体的不稳定性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号