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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >Genome-wide distribution of DNA methylation and DNA demethylation and related chromatin regulators in cancer
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Genome-wide distribution of DNA methylation and DNA demethylation and related chromatin regulators in cancer

机译:全基因组DNA甲基化和DNA脱甲基化及相关染色质调节剂在癌症中的分布

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摘要

DNA methylation plays an important role in the regulation of gene expression, as it is the first epigenetic modification to take place on a given DNA strand. Several factors may directly or indirectly regulate the dynamic distribution of DNA methylation and demethylation between intergenic and intragenic gene regions, thereby controlling gene expression. CpG islands have direct implications for the understanding of DNA methylation patterns in normal conditions and in some common disease states, including cancer. Here, we summarize several recent studies on the genome-wide distribution of DNA methylation and demethylation and their related factors, and we discuss the potential of DNA methylation and demethylation patterns to contribute to gene transcription patterns in tumorigenesis.
机译:DNA甲基化在基因表达的调节中起着重要作用,因为它是在给定DNA链上发生的第一个表观遗传修饰。几个因素可以直接或间接调节基因间和基因内基因区域之间DNA甲基化和去甲基化的动态分布,从而控制基因表达。 CpG岛对于正常条件和某些常见疾病(包括癌症)中DNA甲基化模式的理解具有直接的意义。在这里,我们总结了DNA甲基化和脱甲基化及其相关因素的全基因组分布的近期研究,我们讨论了DNA甲基化和脱甲基化模式有助于肿瘤发生中基因转录模式的潜力。

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