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首页> 外文期刊>Microbial drug resistance: MDR : Mechanisms, epidemiology, and disease >Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China
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Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China

机译：基因型B基因型B与基因型C乙型肝炎病毒感染患者的耐药突变检测率和抗药性突变突变模式的比较

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摘要

The study aimed to investigate the association of prevalent genotypes in China (HBV/C and HBV/B) with HBV drug-resistant mutations. A total of 13,847 nucleos(t) ide analogue (NA)-treated patients with chronic HBV infection from North China were enrolled. HBV genotypes and resistant mutations were determined by direct sequencing and confirmed by clonal sequencing if necessary. HBV/B, HBV/C, and HBV/D occupied 14.3%, 84.9%, and 0.8% across the study population, respectively. NA usage had no significant difference between HBV/B- and HBV/C-infected patients. Lamivudine-resistant mutations were more frequently detected in HBV/C-infected patients, compared with HBV/B-infected patients (31.67% vs. 25.26%, p < 0.01). Adefovir- and entecavir-resistant mutation detection rates were similar, but the mutational pattern was different between the two genotypes. For adefovir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtA181V (HBV/C 5.29% vs. HBV/B 1.36%, p < 0.01) and a lower detection rate of rtN236T (2.70% vs. 6.54%, p < 0.01). For entecavir-resistant mutations, HBV/C-infected patients had a higher detection rate of rtM204 V/ I+T184 substitution or S202G/C (3.66% vs. 2.16%, p < 0.01) and a lower detection rate of rtM204 V/I+M250 V/ I/L substitution (0.67% vs. 1.46%, p < 0.01). Multidrug-resistant mutations (defined as coexistence of mutation to nucleoside and nucleotide analogues) were detected in 104 patients. HBV/C-infected patients had a higher detection rate of multidrug-resistant mutation than HBV/B-infected patients (0.83% vs. 0.35%, p < 0.05). The study for the first time clarified that HBV/C-infected patients had a higher risk to develop multidrug-resistant mutations, compared with HBV/B-infected patients; and HBV/C-and HBV/B-infected patients had different inclinations in the ETV-resistant mutational pattern.
机译：该研究旨在探讨中国（HBV / C和HBV / B）的普遍基因型与HBV耐药性突变的关联。注册了总共13,847个核（T）IDE类似物（NA） - 治疗华北慢性HBV感染患者。通过直接测序并通过克隆测序的直接测序确定HBV基因型和抗性突变。 HBV / B，HBV / C和HBV / D分别在研究人群中占14.3％，84.9％和0.8％。 HBV / B-和HBV / C感染患者之间没有显着差异。与HBV / C感染的患者中更频繁地检测到抗拉米夫定突变，与HBV / B感染患者相比（31.67％对25.26％，P <0.01）。 AdeFovir-和敌合抗性突变检测率类似，但两种基因型之间的突变模式不同。对于抗甲醛抗性突变，HBV / C感染患者的RTA181V检出率较高（HBV / C 5.29％对HBV / B 1.36％，P <0.01）和较低的RTN236T检出率（2.70％与6.54 ％，p <0.01）。对于抗营养剂抗突变，HBV / C感染患者的RTM204 V / I + T184的检出率较高或S202G / C（3.66％与2.16％，P <0.01）和RTM204 V /的较低检测率I + M250 V / I / L替代（0.67％与1.46％，P <0.01）。在104名患者中检测到多药抗突变（定义为对核苷和核苷酸类似物的突变的共存）。 HBV / C感染的患者的多药抗突变检出率高于HBV / B感染患者（0.83％vs.0.35％，P <0.05）。与HBV / B感染患者相比，第一次第一次澄清了HBV / C感染患者的风险较高，抗性抗性抗突变风险较高;和HBV / C-and HBV / B感染的患者在耐ETV抗性突变模式下具有不同的倾向。

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  • 来源
  • 作者

    Li Xiaodong; Liu Yan; Xin Shaojie; Ji Dong; You Shaoli; Hu Jinhua; Zhao Jun; Wu Jingjing; Liao Hao; Zhang Xin-Xin; Xu Dongping;

  • 作者单位

    Beijing 302 Hosp Res Ctr Clin &

    Translat Med 100 Middle St West 4th Ring Rd Beijing 100039;

    Beijing 302 Hosp Res Ctr Clin &

    Translat Med 100 Middle St West 4th Ring Rd Beijing 100039;

    Beijing 302 Hosp Med Ctr Liver Failure Beijing Peoples R China;

    Beijing 302 Hosp Med Ctr Liver Failure Beijing Peoples R China;

    Beijing 302 Hosp Med Ctr Liver Failure Beijing Peoples R China;

    Beijing 302 Hosp Med Ctr Liver Failure Beijing Peoples R China;

    Beijing 302 Hosp Med Ctr Liver Failure Beijing Peoples R China;

    Beijing 302 Hosp Res Ctr Clin &

    Translat Med 100 Middle St West 4th Ring Rd Beijing 100039;

    Beijing 302 Hosp Res Ctr Clin &

    Translat Med 100 Middle St West 4th Ring Rd Beijing 100039;

    Shanghai Jiao Tong Univ Rui Jin Hosp Dept Infect Dis 197 Rui Jin Second Rd Shanghai 200025;

    Beijing 302 Hosp Res Ctr Clin &

    Translat Med 100 Middle St West 4th Ring Rd Beijing 100039;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    hepatitis B virus; drug resistance; genotype;

    机译：乙型肝炎病毒;耐药;基因型;

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