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Vaginal dysbiotic bacteria act as pathobionts of the protozoal pathogen Trichomonas vaginalis

机译：阴道歧视性细菌充当原生动物病原体Trichomonas阴道的病原体

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Trichomoniasis, a prevalent sexually transmitted infection caused by the protozoan parasite Trichomonas vaginalis, is often accompanied by a vaginal dysbiotic microbiota of pathogenic potential. Our objective was to investigate whether these dysbiotic bacteria act as pathobionts of T. vaginalis infection by altering pathogenic capabilities of the parasite, particularly in regard to adhesion to vaginal substrates and viability of human ectocervical cells. Assays interrogated the performance of T. vaginalis adhesion to biofilm produced by vaginal dysbiotic bacteria and whether these bacteria were capable of altering the ability of the parasite to bind to mucins and cells. The binding activities of T. vaginas were quantified by flow cytometry. Host cell viability and apoptosis, as affected by T. vaginalis with or without the bacteria, were also measured experimentally. An in vitro biofilm was shown to provide adhesion for T. vaginalis. The binding of parasites to mucins and cells was modulated by the vaginal dysbiotic bacteria. Parasite cytoadhesion was significantly increased by these bacteria. In addition, these bacteria enhanced the pathogenic effects of the parasite to host cells. Together, this study showed that dysbiotic bacteria accompanying T. vaginalis infection in the vagina function as pathobionts as they are capable of enhancing the pathogenic capabilities of this parasite. This study highlights the importance of understanding the contribution of the vaginal microbiome to trichomoniasis.
机译：Trichomoniaisis是由原生动物寄生虫Trichomonas阴道引起的流动传播的感染，通常伴随着病原潜力的阴道歧视微生物。我们的目标是通过改变寄生虫的致病能力，探讨这些歧化菌是否充当阴道感染的病症，特别是在对阴道底物和人氏菌细胞的可生存力方面。测定询问通过阴道歧视细菌产生的生物膜的粘膜与生物膜的性能，以及这些细菌是否能够改变寄生虫与粘蛋白和细胞结合的能力。通过流式细胞术量化T.Gaginas的结合活性。在实验上还测量受到细菌的T.阴道影响的宿主细胞活力和凋亡。显示了体外生物膜，为阴道提供粘附。寄生虫对粘液和细胞的结合被阴道歧视性细菌调节。这些细菌寄生虫细胞凋亡显着增加。此外，这些细菌增强了寄生虫对宿主细胞的致病作用。这项研究表明，阴道伴随着阴道阴道症感染的歧疲力性细菌作为病原体，因为它们能够提高该寄生虫的致病能力。本研究强调了了解阴道微生物组对滴毛病的重要性。

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