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Proteobiotics as a new antimicrobial therapy

机译:proteobiotics作为一种新的抗菌治疗

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Antibiotic resistance is a major concern for healthcare. The emergence of resistant bacteria has contributed to an increase in cost, morbidity, and mortality rates of patients. There is evidence to suggest that the inhibition of bacteria's virulence strategies would downregulate their pathogenesis and stop infections while also preventing more resistance. This concept became the backbone of many studies in the arena of human microbiome. Through probiotic studies, novel compounds were discovered that possessed antimicrobial activity. These have become labeled as proteobiotics, i.e. metabolites from probiotics. Proteobiotics have demonstrated the ability to interrupt bacteria cell-to-cell communication. Currently, there is one approved product containing proteobiotic technologies for swine showing positive outcomes.
机译:抗生素抗性是医疗保健的主要关注点。 抗性细菌的出现导致成本,发病率和患者死亡率的增加。 有证据表明,抑制细菌的毒力策略将下调其发病机制并停止感染,同时还可以防止更多的阻力。 这一概念成为人类微生物组竞技场中许多研究的骨干。 通过益生菌研究,发现具有抗微生物活性的新化合物。 这些已被标记为proteobiotics,即来自益生菌的代谢物。 Proteobiotics已经证明了中断细菌细胞对细胞通信的能力。 目前,有一种批准的产品,含有蛋白质技术的猪,显示出阳性结果。

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