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Development of vaccines for prevention of peste-des-petits-ruminants virus infection

机译:用于预防Peste-Des-Petits-反刍动物病毒感染的疫苗的开发

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Peste des petits ruminants (PPR) is a highly contagious and fatal disease of small ruminants, particularly sheep and goats. This disease leads to high morbidity and mortality of small ruminants, thus resulting in devastating economic loss to the livestock industry globally. The severe disease impact has prompted the Food and Agriculture Organization of the United Nations (FAO) and the World Organization for Animal Health (OIE) to develop a global strategy for the control and eradication of PPR by 2030. Over the past decades, the control of PPR is mainly achieved through vaccinating the animals with live-attenuated vaccines, e.g., rinderpest vaccines. As a closely related disease to PPR of large ruminants, rinderpest was eradicated in 2011 and its vaccines subsequently got banned in order to keep rinderpest-free zones. Consequently, it is desirable to develop homologous PPR vaccines to control the disease. The present review summarizes the objectives of PPR control and eradication by focusing on the homologous PPR vaccines.
机译:Peste des Petits反刍动物(PPR)是小反刍动物,特别是绵羊和山羊的高度传染性和致命的疾病。这种疾病导致小型反刍动物的发病率和死亡率高,因此导致全球畜牧业的经济损失造成毁灭性。严重的疾病影响促使联合国(粮农组织)和世界动物健康组织(OIE)促成了粮食和农业组织,为2030年举办了对普尔的控制和消除PPR的全球战略。在过去的几十年中,控制PPR主要通过用活衰减的疫苗接种动物,例如RinderPest疫苗接种动物来实现。作为对大型反刍动物的PPR密切相关的疾病,2011年的Rinderpest被删除,其疫苗随后被禁止以保持无渣油区域。因此,希望开发同源PPR疫苗以控制疾病。本综述总结了通过专注于同源PPR疫苗的PPR控制和消除的目标。

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