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首页> 外文期刊>Microbial Pathogenesis >Comparative analysis of gut microbial community in healthy and tibial dyschondroplasia affected chickens by high throughput sequencing
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Comparative analysis of gut microbial community in healthy and tibial dyschondroplasia affected chickens by high throughput sequencing

机译：通过高通量测序对健康微生物群落肠道微生物群落的比较分析

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Tibial dyschondroplasia (TD) is a common skeletal problem of avian species. The cause and etiology of this disorder is still not clear. The intestinal bacterial community is a complex ecosystem and plays very important role in healthy life of human and animals. Many researchers have made the connection between diseases and alteration of gut microbiota. However, little is know about the role of gut microbiota in TD. The objective of this study was to explore the diversity and composition of small and large intestinal bacterial communities of TD chickens. The intestinal contests were collected from healthy and TD chickens at day 18 of the trail. The V3-V4 region of 16S rDNA was amplified and sequenced by high-throughput sequencing. Our results indicated that healthy chickens had higher abundance and diversity of gut microbiota than TD chickens but there was no significant difference (P & 0.05) among the gut microbiota of small and large intestine. However, the composition of bacterial communities were significantly different (P & 0.05) between healthy and TD chickens. The occurrence of gut pathogens associated with immunity and inflammation were much higher in the intestinal contests of TD chickens as compared to healthy ones. In summary, our results showed an interesting difference of gut microbiota between healthy and TD chickens, which provided a new thought about the pathogenesis of TD.
机译：胫骨缺陷（TD）是禽类的常见骨骼问题。这种疾病的原因和病因尚不清楚。肠道细菌群落是一种复杂的生态系统，在人类和动物的健康生活中起着非常重要的作用。许多研究人员已经在疾病和肠道微生物的改变之间取得了联系。然而，很少知道Gut Microbiota在TD中的作用。本研究的目的是探讨TD鸡的小肠细菌群落的多样性和组成。在小径的第18天，从健康和TD鸡收集肠比赛。通过高通量测序扩增16S rDNA的V3-V4区域和测序。我们的结果表明，健康的鸡具有比TD鸡的肠道微生物群更高丰富和多样性，但在小肠道的肠道微生物群中没有显着差异（p＆amp; 0.05）。然而，在健康和TD鸡之间的细菌群落的组成显着不同（P＆amp; 0.05）。与健康的肠道TD鸡的肠道肠比赛中，肠道肠比赛中的肠道病原体发生得多。总之，我们的结果表明，健康和TD鸡之间肠道微生物群的有趣差异，为TD发病机制提供了新的思考。

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