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首页> 外文期刊>BJU international >Prognostic impact of carbonic anhydrase IX expression in human renal cell carcinoma.
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Prognostic impact of carbonic anhydrase IX expression in human renal cell carcinoma.

机译：碳酸酐酶IX表达在人肾细胞癌中的预后影响。

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摘要

OBJECTIVE To evaluate the prognostic information of carbonic anhydrase (CA) IX expression in patients with renal cell carcinoma (RCC), as increased expression of CA IX is correlated with a worse prognosis in several malignancies. PATIENTS AND METHODS CA IX expression was assessed in RCC tumours from 228 patients, using a tissue microarray technique on archival material. The expression was related to RCC cell type, Tumour-Node-Metastasis (TNM) stage, nuclear grade and survival. RESULTS CA IX expression was significantly higher (P < 0.001) in 183 conventional than in 31 papillary RCC and 14 chromophobe RCC. For conventional RCC there was no correlation of CA IX expression with TNM stage or nuclear grade. To evaluate the prognostic information conventional RCC tumours were subdivided arbitrarily into three groups according to the CA IX expression, of 0-10%, 11-90% and 91-100% expression, respectively. Patients with tumours with 0-10% expression had a less favourable prognosis than those with 11-90% and 91-100% expression (P = 0.012, and 0.001), respectively. A multivariate analysis of prognostic factors for patients with conventional RCC showed that TNM stage, nuclear grade and CA IX were independent predictors of prognosis. CONCLUSION These results show that CA IX expression is higher in conventional than other RCC cell types; furthermore, patients with conventional RCC with low CA IX expression had a less favourable prognosis.
机译：目的评估碳酸酐酶（CA）IX在肾细胞癌（RCC）患者中的预后信息，因为CA IX表达的增加与几种恶性肿瘤的预后不良相关。患者和方法使用组织微阵列技术在档案材料上评估了228例RCC肿瘤中CA IX的表达。该表达与RCC细胞类型，肿瘤节点转移（TNM）阶段，核等级和存活率有关。结果183例常规CA IX的表达显着高于31例乳头状RCC和14个发色团RCC（P <0.001）。对于常规RCC，CA IX表达与TNM分期或核分级无相关性。为了评估预后信息，根据CA IX的表达将常规的RCC肿瘤分为三类，分别为0-10％，11-90％和91-100％。表达为0-10％的肿瘤患者的预后要比表达为11-90％和91-100％的患者低（P = 0.012和0.001）。常规RCC患者的预后因素的多因素分析表明，TNM分期，核分级和CA IX是预后的独立预测因子。结论这些结果表明，常规方法中CA IX的表达高于其他RCC细胞类型。此外，CA IX低表达的常规RCC患者预后较差。

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