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首页> 外文期刊>Microvascular Research: An International Journal >Resting cerebral blood flow alterations specific to the comitant exophoria patients revealed by arterial spin labeling perfusion magnetic resonance imaging
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Resting cerebral blood flow alterations specific to the comitant exophoria patients revealed by arterial spin labeling perfusion magnetic resonance imaging

机译：休息特异于动脉旋转标记灌注磁共振成像的术语脑血流改变特异性患者

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PurposeIt has been shown in many previous studies that there were significant changes of the brain anatomy and function in strabismus. However, the significance of the alterations of resting cerebral blood flow (CBF) in comitant exophoria (CE) remains obscure. Arterial spin labeling (ASL) MRI, which is a noninvasive method, could be applied to detect the cerebral blood flow quantitatively. Our study aimed to compare the resting CBF between the comitant exophoria and health controls using pseudo-continuous arterial spin labeling (pCASL) perfusion MRI method. Methods32 patients (25 males and 7 females) with CE (study group), and 32 (25 males and 7 females) healthy individuals with matched age and sex status (control group) underwent a whole-brain pCASL magnetic resonance (MR) examination at the resting state. The resting CBF were voxel-wise compared between the two groups using an analysis of variance designed in a statistical parametric mapping program. The CE patients were distinguishable from the healthy controls (HCs) by receiver operating characteristic (ROC) curves. ResultsCompared with the control group, the CE group showed significantly increased resting CBF values in the right parahippocampal regions, bilateral medial frontal gyrus/anterior cingulate cortex, left inferior frontal gyrus, right inferior frontal gyrus, left superior frontal gyrus, bilateral medial cingulate cortex, right middle frontal gyrus, and right paracentral lobule. ConclusionComitant exophoria showed increased resting CBF in eye movement-related brain areas including supplementary eye field, cingulate eye field and frontal eye field, which could be an explanation of the brain function compensation for the ocular motility disorders in the CE patients.
机译：目的在许多先前的研究中已经显示出脑部解剖学和斜视功能的显着变化。然而，静息脑血流（CBF）改变在显着的exophoria（CE）中的改变仍然模糊不清。可以应用于非侵入方法的动脉旋转标记（ASL）MRI定量检测脑血流量。我们的研究旨在使用伪连续动脉旋转标记（PCASL）灌注MRI方法比较静态外贫药与健康控制之间的静息CBF。方法对患者（25名男性和7名女性），CE（研究组）和32名（25名男性和7名女性）健康个体，具有匹配年龄和性别地位（对照组），经历了全脑PCASL磁共振（MR）检查休息状态。使用在统计参数映射程序中设计的方差分析，静止的CBF是Voxel-Wise与两组之间的比较。 CE患者可与接收器操作特征（ROC）曲线的健康对照（HCS）分开。结果与对照组，CE集团在右侧综合池地区，双侧内侧前旋转梗塞皮层，左下额相回到，右下额相，左前额相，双侧额相回到，双侧额相回到，双侧额相旋转，双侧内侧刺伤皮质，右中正面的转象，右侧斜纹。结论综合偏见表明，眼球运动相关脑区域中的休息CBF增加，包括补充眼睛场，挤出眼睛场和额头眼域，这可能是CE患者中眼动力障碍的脑功能补偿的解释。

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