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HIV tropism assays when first CCR5-antagonist becomes available

机译：当第一个CCR5-拮抗剂可用时，艾滋病毒的热衷测定

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Since its co-receptors were discovered, HIV tropism is defined by the type of co-receptor used to infect its host cells : R5 for Viruses using only CCR5, X4 for viruses using only CXCR4. and R5/X4 or dual for viruses using either CCR5 or CXCR4. Tropism prediction actually made is via recombinant phenotypic assays, which are labour-intensive, long-lasting and expensive. available in only a few highly qualified laboratories. Prescription of CCR5-antagonists requires screening for the presence of X4 variants before starting therapy. With development of this new class of antiretrovirals there is a need for genotypic tests, based on V3 loop gp 120 env, gene sequencing and its interpretation with an algorithm. As for resistance tests 10 years ago, these genotypic tests will be easier to introduce into routine clinical practice. These genotypic tropism assays will help to select patients before CCR5-antagonist prescription and to follow patients treated by this class of antiretrovirals. looking for a potential switch of tropism during therapy. (C)2008 Elsevier Masson SAS. Tous droits reserves.
机译：由于发现了其共同受体，因此艾滋病毒的热衷是由用于感染其宿主细胞的共同受体的类型定义：仅使用CXCR4使用CCR5，X4的病毒R 5。使用CCR5或CXCR4的病毒R5 / X4或双重。实际上取得的热感预测是通过重组表型测定，这是劳动密集型，持久且昂贵的。只有一些高素质的实验室。 CCR5-拮抗剂的处方需要在开始治疗前筛选X4变体的存在。随着这类新类抗逆转录病毒的发展，基于V3环GP 120 Env，基因测序及其用算法的解释需要基因型测试。至于10年前的抗性测试，这些基因型测试将更容易引入常规临床实践。这些基因型的热衷测定将有助于选择CCR5-拮抗剂处方前的患者，并遵循这类抗逆转录病毒治疗的患者。在治疗过程中寻找潜在的转向转换。 （c）2008 Elsevier Masson SAS。艺术店储备。

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