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首页> 外文期刊>Molecular Biology >Increase in Bacterial Resistance to Antibiotics after Cancer Therapy with Platinum-Based Drugs
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Increase in Bacterial Resistance to Antibiotics after Cancer Therapy with Platinum-Based Drugs

机译：用铂类药物治疗癌症治疗后对抗生素的细菌耐药性增加

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The use of platinum-based anticancer drugs is limited by both their side effects and their effect on normal microflora's metagenome. Drugs that possess mutagenic and genotoxic properties may cause mutations in microbial genomes that contribute to the emergence of resistance to antimicrobial preparations and the development of complications after chemotherapy. The effects of cisplatin and oxaliplatin on microorganisms were studied using bacterial biosensors-E. coli strains MG1655 pKatG-lux, which reacts to the generation of hydrogen peroxide; MG1655 pSoxS-lux, which reacts to the superoxide anion radical; and the MG1655 pColD-lux strain, which detects DNA damage. The biosensor tests demonstrated high levels of genotoxicity for both drugs and some differences in the spectrum of reactive oxygen species generated. Ascorbate reduced genotoxicity of cisplatin by 41%. Nonlethal doses of cisplatin induced a three- to sevenfold increase in the frequency of the mutations that confer the resistance of E. coli to rifampicin and ciprofloxacin. Ascorbate also reduced frequency of the mutations by 65%. Thus, the effect of these drugs was probably associated with the generation of reactive oxygen species and induction of SOS response. The risk of secondary antibiotic-resistant infections may be decreased by applying antioxidants and antimutagens. At the same time, these increases may also decrease the anti-tumoral action of these compounds.
机译：铂族基抗癌药物的使用受到它们的副作用及其对正常微氟勒拉的偏见的影响。具有诱变和遗传毒性特性的药物可能导致微生物基因组中的突变，这有助于出现抗菌制剂的抗性和化疗后并发症的发展。使用细菌生物传感器-E研究了顺铂和奥沙利铂对微生物的影响。大肠杆菌菌株MG1655 PKATG-LUX，反应于过氧化氢的产生; Mg1655 Psoxs-Lux，对超氧化物阴离子的反应;和MG1655 PCold-Lux菌株，检测DNA损坏。生物传感器测试表明药物的高水平遗传毒性以及产生的反应性氧物种的光谱差异。抗坏血性降低了顺铂的遗传毒性41％。非致畸剂量的顺铂诱导突变突变的三到七倍的增加，该突变赋予大肠杆菌与利福平和环丙沙星的抗性。抗坏血酸还将突变的频率降低65％。因此，这些药物的效果可能与产生活性氧物质的产生和SOS反应的诱导有关。通过涂覆抗氧化剂和抗毒剂，可以降低继发性抗性感染的风险。同时，这些增加也可能降低这些化合物的抗肿瘤作用。

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