• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular and Cellular Endocrinology >Seasonal reproductive state determines gene expression in the hypothalamus of a latitudinal migratory songbird during the spring and autumn migration
【24h】

Seasonal reproductive state determines gene expression in the hypothalamus of a latitudinal migratory songbird during the spring and autumn migration

机译：季节性生殖状态决定了春季迁移期间纬度迁徙鸣禽的下丘脑中的基因表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We investigated gonadal effects on hypothalamic transcription of genes in sham-operated and castrated redheaded buntings photostimulated into spring and autumn migratory states. RNA-Seq results showed testes-dependent differences between spring and autumn migratory states. In particular, differentially expressed genes enriched G-protein-coupled receptor and calcium-ion signaling pathways during spring and autumn states, respectively. qPCR assay showed attenuated gabra5, ttr, thra and thrb expressions, suggesting reduced GABA and thyroid hormone effects on photo-sexual response in spring. In spring castrates, reduced npy, tac1 and nrcam and increased ank3 expression suggested testicular effects on the appetite, prolactin release and neuronal functions, whereas in autumn castrates, reduced rasgtp1, grin5 and grin1, and increased mras expression suggested testicular effects on the ras, G-protein and glutamate signaling pathways. Castration-induced reciprocal switching of pomc and pdyn expressions suggested effects on the overall homeostasis in both seasons. These results demonstrate transcriptome-wide changes, with season-dependent roles of testes in songbird migration.
机译：我们调查了对假刺破的假手术和阉割的红发自杀基因的下丘脑转录的Gonadal效应是光刺激成春季和秋季迁移状态。 RNA-SEQ结果表明春季和秋季迁徙状态之间的依赖差异。特别地，差异表达基因分别在春季和秋季状态下富集G蛋白偶联受体和钙离子信号传导途径。 QPCR测定显示衰减的GABRA5，TTR，THRA和THRB表达，表明GABA和甲状腺激素对春季光学反应的影响。在春季阉割中，降低NPY，TAC1和NRCAM并增加ANK3表达提出了对食欲，催乳素释放和神经元功能的睾丸作用，而在秋季阉割中，减少的RASGTP1，GRIN5和GRIN1，以及增加的MRAS表达在RAS上提出了睾丸影响，提出了对RA的睾丸效应。 G蛋白和谷氨酸信号传导途径。阉割诱导的POMC和PDYN表达的互惠交换建议对两个季节的整体稳态作用。这些结果证明了转录组的变化，在鸣禽迁移中具有季节依赖性作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号