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首页> 外文期刊>Addiction biology >(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake
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(R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake

机译：（R）-Salsolinol，乙醇代谢产物，立体定向诱导行为敏化并导致过量酒精摄入

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Ethanol is oxidized in the brain to acetaldehyde, which can condense with dopamine to generate (R/S)-salsolinol [(RS)-SAL]. Racemic salsolinol [(RS)-SAL] is self-infused by rats into the posterior ventral tegmental area (VTA) at significantly lower concentrations than those of acetaldehyde, suggesting that (RS)-SAL is a most active product of ethanol metabolism. Early studies showed that repeated intraperitoneal or intra-VTA administration of (RS)-SAL (10mg/kg) induced conditioned place preference, led to locomotor sensitization and increased voluntary ethanol consumption. In the present study, we separated the (R)- and (S)-enantiomers from a commercial (RS)-SAL using a high-performance liquid chromatography with electrochemical detection system fitted with a -cyclodextrin-modified column. We injected (R)-SAL or (S)-SAL (30pmol/1.0l) into the VTA of naive UChB rats bred as alcohol drinkers to study whether one or both SAL enantiomers are responsible for the motivated behavioral effects, sensitization and increase in voluntary ethanol intake. The present results show that repeated administration of (R)-SAL leads to (1) conditioned place preference; (2) locomotor sensitization; and (3) marked increases in binge-like ethanol intake. Conversely, (S)-SAL did not influence any of these parameters. Overall, data indicate that (R)-SAL stereospecifically induces motivational effects, behavioral sensitization and increases ethanol intake.
机译：乙醇在大脑中被氧化为乙醛，乙醛可以与多巴胺凝结生成（R / S）-salsolinol [（RS）-SAL]。外消旋的Salsolinol [（RS）-SAL]是大鼠自体注入后腹侧被盖区（VTA）的浓度，其浓度明显低于乙醛，这表明（RS）-SAL是乙醇代谢最活跃的产物。早期研究表明，反复腹膜内或VTA内（RS）-SAL（10mg / kg）给药可引起条件性位置偏爱，导致运动敏化和自愿性乙醇消耗增加。在本研究中，我们使用高效液相色谱仪和配备了环糊精修饰柱的电化学检测系统，从市售（RS）-SAL中分离了（R）-和（S）-对映体。我们将（R）-SAL或（S）-SAL（30 pmol/1.0l）注入以酒精为食的幼稚UChB大鼠的VTA中，以研究一种或两种SAL对映异构体是否对行为动机，敏化和增加有影响。自愿摄入乙醇。目前的结果表明，重复施用（R）-SAL可导致（1）条件性位置偏爱; （2）运动敏化; （3）暴饮暴食的乙醇摄入量显着增加。相反，（S）-SAL不会影响任何这些参数。总体而言，数据表明（R）-SAL立体定向诱导动机作用，行为敏化并增加乙醇摄入。

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