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首页> 外文期刊>Molecular phylogenetics and evolution >Comprehensive codon usage analysis of porcine deltacoronavirus
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Comprehensive codon usage analysis of porcine deltacoronavirus

机译：普罗素德尔特拉戈卢斯的综合密码子使用量分析

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摘要

Porcine deltacoronavirus (PDCoV) is a newly identified coronavirus of pigs that was first reported in Hong Kong in 2012. Since then, many PDCoV isolates have been identified worldwide. In this study, we analyzed the codon usage pattern of the S gene using complete coding sequences and complete PDCoV genomes to gain a deeper understanding of their genetic relationships and evolutionary history. We found that during evolution three groups evolved with a relatively low codon usage bias (effective number of codons (ENC) of 52). The factors driving bias were complex. However, the primary element influencing the codon bias of PDCoVs was natural selection. Our results revealed that different natural environments may have a significant impact on the genetic characteristics of the strains. In the future, more epidemiological surveys are required to examine the factors that resulted in the emergence and outbreak of this virus.
机译：猪Deltacoronavirus（Pdcov）是2012年在香港首次报道的新发现的猪冠状病毒。从那时起，许多PDCov孤立株均在全球范围内识别出来。 在这项研究中，我们使用完整的编码序列分析了S基因的密码子使用模式，并完成PDCOV基因组，以获得更深入地了解其遗传关系和进化史。 我们发现在演化期间，三组随着相对低的密码子使用偏差而演进（有效数量的密码子（ENC）为52）。 驾驶偏见的因素很复杂。 然而，影响PDCOV的密码子偏压的主要元素是自然选择。 我们的研究结果表明，不同的自然环境可能对菌株的遗传特征产生重大影响。 将来，需要更多的流行病学调查来检查导致这种病毒的出现和爆发的因素。

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  • 来源
    《Molecular phylogenetics and evolution》 |2019年第2019期|共10页
  • 作者

    He Wei; Wang Ningning; Tan Jimin; Wang Ruyi; Yang Yichen; Li Gairu; Guan Haifei; Zheng Yuna; Shi Xinze; Ye Rui; Su Shuo; Zhou Jiyong;

  • 作者单位

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ MOE Joint Int Res Lab Anim Hlth &

    Food Safety Jiangsu Engn Lab Anim Immunol Inst Immunol Nanjing 210095 Jiangsu Peoples R China;

    Zhejiang Univ MOA Key Lab Anim Virol Dept Vet Med Hangzhou 310058 Zhejiang Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 进化遗传学;
  • 关键词

    PDCoV; Codon usage; Mutation pressure; Nature selection; Evolution;

    机译：pdcov;密码子使用;突变压力;自然选择;进化;

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