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首页> 外文期刊>Addiction biology >Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration.
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Rising taurine and ethanol concentrations in nucleus accumbens interact to produce dopamine release after ethanol administration.

机译：服用乙醇后，伏隔核中牛磺酸和乙醇浓度的升高相互作用，产生多巴胺释放。

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We have previously demonstrated that glycine receptors in the nucleus accumbens (nAc) are involved in modulating both basal and ethanol-induced dopamine output in the same brain region. Ethanol is known to induce a release of both taurine and dopamine in the nAc, but the relationship between these two neuromodulators has not been investigated thoroughly. In vivo microdialysis was used to measure the effects of systemic ethanol diluted in isotonic (0.9% NaCl) or hypertonic (3.6% NaCl) saline on accumbal taurine and dopamine levels. We found that ethanol given in a hypertonic solution, contrary to an isotonic solution, failed to increase concentrations both of taurine and dopamine in the nAc. However, a modest, non-dopamine elevating concentration of taurine in the nAc disclosed a dopamine-elevating effect of systemic ethanol also when given in a hypertonic solution. In a second experiment, we investigated the effects of ethanol on taurine and dopamine in normal rats and rats with decreased levels of endogenous taurine. Lowering the level of taurine, approximately 40% by adding 5% beta-alanine in the drinking water, did not influence taurine or dopamine output over time. We conclude that the elevations of taurine and dopamine in the nAc are closely related, and that in order for ethanol to induce dopamine release, a simultaneous increase of extracellular taurine levels in the nAc is required. These data also provide support for the notion that the nAc is the primary target for ethanol in its dopamine-activating effect after systemic administration.
机译：先前我们已经证明伏伏核（nAc）中的甘氨酸受体参与调节同一大脑区域中基础和乙醇诱导的多巴胺输出。已知乙醇会诱导牛磺酸和多巴胺在nAc中释放，但是尚未对这两种神经调节剂之间的关系进行彻底研究。体内微透析用于测量在等渗（0.9％NaCl）或高渗（3.6％NaCl）盐水中稀释的全身性乙醇对牛磺酸和多巴胺水平的影响。我们发现，与等渗溶液相反，在高渗溶液中给予的乙醇无法增加nAc中牛磺酸和多巴胺的浓度。但是，nAc中牛磺酸的适度，非多巴胺升高浓度也表明，当在高渗溶液中给药时，全身乙醇的多巴胺升高效果。在第二个实验中，我们研究了乙醇对正常大鼠和内源性牛磺酸水平降低的大鼠中牛磺酸和多巴胺的影响。通过在饮用水中添加5％β-丙氨酸来降低牛磺酸水平（约40％），并不会影响牛磺酸或多巴胺随时间的推移。我们得出结论，nAc中牛磺酸和多巴胺的升高密切相关，为了使乙醇诱导多巴胺释放，需要同时增加nAc中细胞外牛磺酸的水平。这些数据也为以下观点提供了支持：nAc是全身性给药后多巴胺激活作用中乙醇的主要靶标。

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