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首页> 外文期刊>Addiction biology >Examining the role of oxytocin in the interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') using a drug discrimination paradigm in the rat.
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Examining the role of oxytocin in the interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') using a drug discrimination paradigm in the rat.

机译：在大鼠中使用药物鉴别范例检查催产素在3,4-亚甲二氧基甲基苯丙胺（MDMA，'摇头丸'）的互感作用中的作用。

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3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') use results in distinctive mood changes of a prosocial nature, most likely through its enhancement of serotonin (5HT) neurotransmission. Activation of 5HT-1A postsynaptic receptors has been shown to stimulate the release of oxytocin in the central nervous system where it regulates aspects of mood and behavior. Using a drug discrimination paradigm, we examined whether modulation of oxytocin receptor activity would affect conditioned behavioral responses to MDMA. Male and female Sprague Dawley rats (n=24) were trained to reliably differentiate between MDMA and a related stimulant, amphetamine (AMP), and saline using a three-lever drug discrimination paradigm. The extent to which substitution with carbetocin (an oxytocin analog) or co-administration with atosiban (an oxytocin receptor antagonist) affected drug-appropriate responding was evaluated. The tricyclic antidepressant imipramine was included as a negative control. The results supported the hypotheses that substitution with an oxytocin analog (carbetocin) would partially generalize to the MDMA training cue, whereas blocking oxytocin receptors with atosiban would result in a selective disruption of MDMA--but not AMP-appropriate responding. These findings were specific to the oxytocin receptor ligands as imipramine pre-treatment did not affect drug-appropriate responding. The results of this study implicate oxytocin receptor activation as a key MDMA-specific interoceptive cue in male and female rats and support the conclusion that this is one of the features of MDMA's subjective effects that distinguishes it from AMP.
机译：3,4-亚甲二氧基甲基苯丙胺（MDMA，“摇头丸”）的使用会导致亲社会性质的明显情绪变化，最有可能是通过增强5-羟色胺（5HT）神经传递引起的。 5HT-1A突触后受体的激活已被证明可以刺激催产素在中枢神经系统中的释放，从而调节情绪和行为。使用药物鉴别范例，我们检查了催产素受体活性的调节是否会影响对MDMA的条件行为反应。雄性和雌性Sprague Dawley大鼠（n = 24）经过训练，可以使用三杆药物歧视范例可靠地区分MDMA与相关的兴奋剂，苯丙胺（AMP）和盐水。评估了用卡比霉素（催产素类似物）替代或与阿托西班（催产素受体拮抗剂）共同给药影响药物适当应答的程度。包括三环抗抑郁药丙咪嗪作为阴性对照。结果支持这样的假设，即用催产素类似物（卡贝托星）替代会部分泛化到MDMA训练提示，而用阿托西班阻断催产素受体会导致MDMA的选择性破坏-但不会产生适合AMP的反应。这些发现是特异于催产素受体配体的，因为丙咪嗪预处理不会影响药物适当的应答。这项研究的结果暗示了催产素受体的激活是雄性和雌性大鼠中MDMA特异的关键感知线索，并支持这一结论，即这是MDMA与AMP区别开来的主观效应之一。

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