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首页> 外文期刊>Addiction biology >Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring.
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Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring.

机译：在严重的酒精依赖中，伏隔核的成功的深部脑刺激与性能监测的改变有关。

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摘要

Following recent advances in neuromodulation therapy for mental disorders, we treated one patient with severe alcohol addiction with deep brain stimulation (DBS) of the nucleus accumbens (NAc). Before and one year following the surgery, we assessed the effects of DBS within the NAc on the addiction as well as on psychometric scores and electrophysiological measures of cognitive control. In our patient, DBS achieved normalization of addictive behavior and craving. An electrophysiological marker of error processing (the error-related negativity) linked to anterior mid-cingulate cortex (aMCC) functioning was altered through DBS, an effect that could be reversed by periods without stimulation. Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction.
机译：继针对精神障碍的神经调节疗法的最新进展后，我们对一名严重酒精成瘾的患者进行了伏伏核（NAc）的深层脑刺激（DBS）。在手术之前和之后的一年，我们评估了NAc中DBS对成瘾以及对认知控制的心理测验得分和电生理指标的影响。在我们的患者中，DBS实现了成瘾行为和渴望的正常化。通过DBS改变了与前扣带回皮层（aMCC）功能相关的错误处理（与错误相关的阴性）的电生理指标，这种效果可以在没有刺激的情况下逆转。因此，本案例支持以下假设：NAc的DBS可能通过与aMCC功能障碍相关的渴望正常化而对成瘾产生积极影响。

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