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首页> 外文期刊>Addiction biology >Naltrexone attenuates amphetamine-induced locomotor sensitization in the rat.
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Naltrexone attenuates amphetamine-induced locomotor sensitization in the rat.

机译：纳曲酮减弱了大鼠中苯丙胺诱导的运动致敏作用。

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Amphetamine, and other stimulants, readily induces behavioral sensitization, an effect hypothesized to reflect neurobiological changes that may underlie certain aspects of drug addiction. Apart from the effects on the dopamine system, previous studies have also shown that amphetamine interacts with other neurotransmitters, including the endogenous opioid system. The unselective opioid receptor antagonist naltrexone (NTX) modulates amphetamine-induced effects in both laboratory animals and humans. To further examine this interaction, the aim of the present study was to investigate the effect of NTX on the expression of locomotor sensitization and conditioned locomotor response in animals previously conditioned with amphetamine. Sensitization was induced by repeated administration of amphetamine (2 mg/kg) for 10 consecutive days. After a 10-day drug-free period, the rats were administered NTX (3 mg/kg) 30 minutes prior to the administration of a challenge dose of either amphetamine (0.5 mg/kg) (test for drug-induced sensitization) or saline (test for conditioned locomotor response). NTX had no effect on acute amphetamine-induced locomotor activity or on general locomotor activity in animals without a history of amphetamine conditioning. However, animals previously conditioned with amphetamine showed a sensitized locomotor response to the amphetamine challenge following the 10-day drug-free period. This sensitized response was significantly inhibited by NTX pre-treatment. In addition, NTX pre-treatment blocked the conditioned locomotor response when the amphetamine-conditioned animals were placed in the previously amphetamine-paired context. This study showed that NTX attenuates drug- and cue-induced locomotor behavior in amphetamine-conditioned animals, supporting recent clinical findings that indicated a potential role of NTX as a treatment for amphetamine dependence.
机译：苯丙胺和其他兴奋剂很容易引起行为敏化，该作用被认为反映了可能是吸毒成瘾某些方面的神经生物学变化。除了对多巴胺系统的影响外，先前的研究还显示苯丙胺与其他神经递质（包括内源性阿片样物质系统）相互作用。非选择性阿片受体拮抗剂纳曲酮（NTX）调节实验动物和人类的苯丙胺诱导的作用。为了进一步检查这种相互作用，本研究的目的是研究NTX对先前用苯丙胺适应的动物的运动敏化和条件性运动反应的表达的影响。连续10天重复服用苯丙胺（2 mg / kg）引起过敏。禁药10天后，在挑战剂量的苯丙胺（0.5 mg / kg）（药物诱导的致敏性测试）或生理盐水给药前30分钟，给大鼠NTX（3 mg / kg） （测试条件性运动反应）。 NTX对没有苯丙胺调理史的动物的急性苯丙胺诱导的运动活性或一般运动活性没有影响。然而，在禁药10天后，先前用苯丙胺调理过的动物对苯丙胺攻击显示出敏锐的运动反应。 NTX预处理显着抑制了这种致敏反应。另外，当将安非他明条件下的动物置于先前安非他命配对的环境中时，NTX预处理会阻断条件下的运动反应。这项研究表明，NTX减弱了苯丙胺调节动物的药物和提示诱导的运动行为，支持了最近的临床发现，这些发现表明NTX在治疗苯丙胺依赖中具有潜在作用。

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