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首页> 外文期刊>Addiction biology >Attenuation of reinforcing and psychomotor stimulant effects of amphetamine by aripiprazole.
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Attenuation of reinforcing and psychomotor stimulant effects of amphetamine by aripiprazole.

机译：阿立哌唑可减轻苯丙胺的增强和精神运动刺激作用。

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Partial dopamine agonists are potential medications for the treatment of amphetamine addiction. They have been hypothesized to stabilize the dopamine system by acting as antagonists during high dopaminergic tone resulting from amphetamine use and as agonists during withdrawal. Aripiprazole is an atypical antipsychotic that acts as a partial D2 dopamine and a serotonin 5-HT(A) agonist and a serotonin 5-HT(A) antagonist. The aim of the present study was to examine the effects of aripiprazole on behaviors induced and maintained by d-amphetamine. To this end, intravenous d-amphetamine self-administration [fixed ratio 3 (FR3) schedule, 0.02 mg/infusion] and d-amphetamine-induced (0, 1.5 mg/kg intraperitoneally) locomotor activity, as well as spontaneous locomotor activity and sucrose pellet selfadministration (FR3 schedule) were studied in male Wistar rats after aripiprazole (0, 0.3, 1, 3 mg/kg i.p.) administration. Aripiprazole pre-treatment resulted in bidirectional effects on amphetamine self-administration. The 1 mg/kg dose increased, and the highest dose decreased the number of amphetamine infusions. In the locomotor activity experiments, aripiprazole attenuated amphetamine-induced activity dose-dependently and tended to suppress spontaneous activity. The highest aripiprazole doses decreased also sucrose pellet self-administration. The increase in amphetamine self-administration with the intermediate aripiprazole dose, as well as the decrease in amphetamine-induced locomotor activity, suggests that aripiprazole acted as a dopamine antagonist. Suppression of amphetamine and sucrose self-administration by the highest aripiprazole dose was probably caused by non-specific effects. Together, these results indicate that under conditions of dopaminergic stimulation, aripiprazole attenuates the reinforcing and psychomotor stimulant effects of d-amphetamine, but the dose range for this effect is rather limited.
机译：多巴胺部分激动剂是治疗苯丙胺成瘾的潜在药物。假设它们通过在苯丙胺使用引起的高多巴胺能音调期间充当拮抗剂并在停药期间充当激动剂来稳定多巴胺系统。阿立哌唑是一种非典型的抗精神病药，可作为部分D2多巴胺和5-羟色胺5-HT（A）激动剂和5-羟色胺5-HT（A）拮抗剂。本研究的目的是研究阿立哌唑对d-苯异丙胺诱导和维持的行为的影响。为此，静脉注射d-苯丙胺自我给药[固定比例3（FR3）时间表，0.02 mg /滴注]和d-苯丙胺诱导的（腹膜内给药，0，1.5 mg / kg）运动能力，以及自发运动能力和在雄性Wistar大鼠中，对阿立哌唑（0，0.3，1，3 mg / kg ip）施用后研究了蔗糖颗粒的自我施用（FR3时间表）。阿立哌唑预处理对苯丙胺自我给药产生双向影响。 1 mg / kg剂量增加，最高剂量减少苯丙胺输注次数。在运动活性实验中，阿立哌唑剂量依赖性地减弱了苯丙胺诱导的活性，并倾向于抑制自发活性。最高阿立哌唑剂量也降低了蔗糖颗粒的自我给药。苯丙胺与中剂量阿立哌唑的自我给药量的增加以及苯丙胺诱导的运动活性的降低，表明阿立哌唑起多巴胺拮抗剂的作用。最高阿立哌唑剂量抑制苯丙胺和蔗糖自我给药可能是由于非特异性作用引起的。总之，这些结果表明，在多巴胺能刺激的条件下，阿立哌唑减弱了d-苯丙胺的增强和精神运动刺激作用，但这种作用的剂量范围相当有限。

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