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首页> 外文期刊>Addiction biology >High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory.
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High cocaine dosage decreases neurogenesis in the hippocampus and impairs working memory.

机译：高可卡因剂量会减少海马中的神经发生并损害工作记忆。

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摘要

Drug addiction is a chronic brain disorder, characterized by the loss of the ability to control drug consumption. The neurobiology of addiction is traditionally thought to involve the mesocorticolimbic system of the brain. However, the hippocampus has received renewed interest for its potential role in addiction. Part of this attention is because of the fact that drugs of abuse are potent negative regulators of neurogenesis in the adult hippocampus and may as a result impair learning and memory. We investigated the effects of different dosages of contingent cocaine on cell proliferation and neurogenesis in the dentate gyrus of the hippocampus and on working memory during abstinence, using the water T-maze test, in adult rats. We found that cocaine, in addition to the changes it produces in the reward system, if taken in high doses, can attenuate the production and development of new neurons in the hippocampus, and reduce working memory.
机译：吸毒成瘾是一种慢性脑部疾病，其特征在于失去控制药物消耗的能力。传统上认为，成瘾的神经生物学涉及大脑的中皮质糖皮质系统。但是，海马因其在成瘾中的潜在作用而引起了新的兴趣。引起这种关注的部分原因是，滥用药物是成年海马中神经发生的有效负调节剂，并可能因此损害学习和记忆。我们使用水T迷宫测试，对成年大鼠研究了不同剂量的可卡因对海马齿状回细胞增殖和神经发生以及禁欲期间工作记忆的影响。我们发现，如果高剂量服用可卡因，除了在奖励系统中产生的变化外，还可以减弱海马中新神经元的产生和发育，并减少工作记忆。

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