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首页> 外文期刊>Addiction biology >A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.
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A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat.

机译：伏伏核内γ-突触核蛋白表达的减少增加了大鼠中可卡因的静脉内自我给药。

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摘要

Except as a marker of cancer progression, gamma-synuclein (GSyn) had received little attention. Recent data showed however that GSyn modulates cocaine-induced locomotor effects, suggesting that it could also play a role in cocaine reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected in the nucleus accumbens and cocaine reinforcing effects were evaluated by means of intravenous self-administration. A dose-response curve was followed by procedures of progressive ratio, extinction, cocaine- and cue-induced reinstatements. Decrease of GSyn expression increased self-administration over a large range of doses. This effect was associated with an increase in cocaine-induced reinstatement. The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects.
机译：除了作为癌症进展的标志物外，γ-突触核蛋白（GSyn）很少受到关注。然而，最近的数据表明，GSyn调节可卡因诱导的运动作用，表明它也可能在可卡因增强作用中起作用。在大鼠中，将靶向GSyn表达的siRNA注射到伏隔核中，并通过静脉内自我给药评估可卡因的增强作用。剂量-反应曲线后是逐步进行比例，消光，可卡因和提示诱导的恢复的程序。 GSyn表达的减少在大剂量范围内增加了自我给药。这种作用与可卡因诱导的恢复增加有关。目前的数据表明，GSyn对可卡因诱导的增强和刺激作用具有特定的负控制作用。

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