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Operant model of frustrated expected reward in mice

机译：沮丧的预期奖励小鼠的手术模型

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One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintained by chocolate-flavoured pellets or cocaine. After the completion of high rates of responding on a progressive ratio schedule, the reward was unexpectedly withheld. The consequences of this frustrated behaviour on anxiety, aggressiveness, perseveration, extinction and reinstatement were investigated. Mice exposed to the frustrated event perseverated in the operant responses and showed increased aggressiveness in the resident intruder test. These animals also showed higher rates of cue-induced reinstatement of drug seeking. The present study provides a reliable operant model in mice to evaluate a frustrated state following reward unavailability. This animal model could be useful to study the behavioural and neurochemical consequences related to the emotional states generated during the omission of a highly expected reward.
机译：上瘾过程的一个方面尚未得到彻底研究，是无法获得药物时沮丧状态的结果。本研究旨在验证小鼠沮丧预期报酬的新型操作模型。 C57BL / 6J小鼠接受了由巧克力味小丸或可卡因维持的操作条件训练。在按比例进行进度的高响应率完成后，意外地取消了奖励。研究了这种沮丧行为对焦虑，攻击性，坚持不懈，绝种和恢复原状的后果。暴露于沮丧事件中的小鼠在操作反应中表现出持久性，并且在常驻入侵者测试中表现出增强的攻击性。这些动物还表现出较高的提示诱导的寻味恢复速度。本研究提供了一种可靠的小鼠手术模型，用于评估奖励不可用后的沮丧状态。这种动物模型可能有助于研究与高度期望的奖励遗漏期间产生的情绪状态有关的行为和神经化学后果。

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