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Characterization of an alcohol addiction-prone phenotype in mice

机译：易饮酒成瘾小鼠表型的表征

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Human studies indicate that high impulsivity, novelty seeking and anxiety predispose individuals to alcohol abuse. Unclear, however, is whether the same phenotypes can be observed in laboratory animals prone to uncontrolled alcohol drinking. To characterize a novelty-seeking trait, anxiety, impulsivity, compulsivity and the motivation for natural rewards in mice, numerous tests were performed in the automated IntelliCage learning system. The same mice then had extended access to alcohol for 70 days, followed by the evaluation of addiction-like behaviors, including (1) the motivation for alcohol in a progressive-ratio schedule of reinforcement; (2) persistent and compulsive alcohol seeking and taking during signaled 'no alcohol' periods and (3) when subjected to punishment; and (4) the intensity of relapse after alcohol withdrawal. Our data suggest that high levels of anxiety-related traits (i.e. low novelty seeking, low resistance to punishment and a high level of compulsive behaviors) and high impulsivity predict addiction-like alcohol drinking in mice. Future studies are, however, warranted to create a valid model of alcohol addiction in mice in the IntelliCage system.
机译：人体研究表明，高冲动性，寻求新颖性和焦虑感使人容易酗酒。然而，尚不清楚在容易受到无节制饮酒的实验动物中是否可以观察到相同的表型。为了表征寻求新奇的特质，焦虑，冲动性，强迫性和小鼠自然奖励的动机，在自动IntelliCage学习系统中进行了许多测试。然后，这些相同的小鼠可以延长饮酒时间达70天，然后评估类似成瘾行为的行为，其中包括：（1）在进行性配比的强化过程中​​饮酒的动机; （2）在“禁止饮酒”信号期间持续不断地强迫性饮酒和服用;以及（3）受到惩罚时; （4）戒酒后复发的强度。我们的数据表明，高水平的焦虑相关性状（即低新奇寻求，低抵抗力和高水平的强迫行为）和高冲动性可预测成瘾性饮酒。但是，有必要进行进一步的研究，以便在IntelliCage系统中为小鼠创建有效的酒精成瘾模型。

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