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首页> 外文期刊>Addiction biology >Activation of the mesostriatal reward pathway with exposure to ultraviolet radiation (UVR) vs. sham UVR in frequent tanners: A pilot study
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Activation of the mesostriatal reward pathway with exposure to ultraviolet radiation (UVR) vs. sham UVR in frequent tanners: A pilot study

机译：经常晒制革的人通过暴露于紫外线辐射（UVR）与假紫外线辐射来激活中胚层奖励途径

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摘要

Frequent and excessive tanning persists despite a growing understanding of its associated morbidity and mortality, suggesting that ultraviolet radiation may impart rewarding effects beyond the assumed cosmetic benefits. To empirically measure putative centrally rewarding properties of ultraviolet radiation (UVR), we assessed the effects of a commercially available tanning bed upon regional cerebral blood flow (rCBF), a measure of brain activity, using single-photon emission computed tomography (SPECT). Seven frequent salon bed tanners were placed under a UVA/UVB tanning light during two sessions; one session with UVR and the other with filtered UVR (sham UVR). Session order was randomized and subjects were blinded to study order. During the UVR session, relative to sham UVR session, subjects demonstrated a relative increase in rCBF of the dorsal striatum, anterior insula and medial orbitofrontal cortex, brain regions associated with the experience of reward. These changes were accompanied by a decrease in the subjective desire to tan. These findings suggest that UVR may have centrally rewarding properties that encourage excessive tanning.
机译：尽管人们对其相关的发病率和死亡率有了越来越多的了解，但仍经常和过度晒黑，这表明紫外线辐射可能会带来超出预期的美容效果的有益效果。为了从经验上衡量假定的紫外线辐射（UVR）的中心奖励特性，我们使用单光子发射计算机断层扫描（SPECT）评估了市售的晒黑床对局部脑血流量（rCBF）的影响，rCBF是衡量大脑活动的指标。在两个疗程中，将七个频繁的美发床制革商置于UVA / UVB晒黑灯下;一个会话使用UVR，另一会话使用过滤的UVR（伪UVR）。会议顺序是随机的，受试者不知道学习顺序。在UVR会话期间，相对于假UVR会话，受试者表现出背纹状体，前岛和内侧眶额皮质，与奖励经历相关的大脑区域的rCBF相对增加。这些变化伴随着棕褐色的主观渴望的降低。这些发现表明，UVR可能具有鼓励过度晒黑的集中奖励特性。

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