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White matter microstructure in opiate addiction

机译：阿片成瘾中的白质微观结构

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Heroin addiction has been associated with impaired neuronal connectivity and cognitive deficits. One mechanism that potentially explains these findings is alterations in white matter connectivity secondary to chronic opiate use. However, few studies have quantitavely examined white matter deficits in opiate addiction (OA). Here, we investigated white matter microstructure in OA using diffusion tensor imaging (DTI). We performed voxel-wise analysis of fractional anisotropy (FA) in 24 participants with OA and 29 healthy controls. The OA group showed reduced FA in multiple pathways including the corpus callosum, thalamic radiation and inferior longitudinal fasciculus. This FA reduction was mainly the result of increased radial diffusivity (λ ⊥), indicative of myelin pathology. Longer duration of OA was also associated with axonal diffusivity (λ 1), most robustly in superior longitudinal fasciculi and right frontal white matter suggesting axonal injury in long-term users. Together, the findings indicate that chronic OA use has widespread and diverse effects on neuronal connectivity and function.
机译：海洛因成瘾与神经元连通性受损和认知缺陷有关。可能解释这些发现的一种机制是继长期使用鸦片制剂后白质连通性的改变。但是，很少有研究定量评估鸦片成瘾（OA）中的白质缺乏。在这里，我们使用扩散张量成像（DTI）研究了OA中的白质微观结构。我们对24名有OA的参与者和29名健康对照者进行了分数各向异性（FA）的体素分析。 OA组在包括call体，丘脑辐射和下纵筋膜在内的多种途径中显示FA降低。 FA降低主要是由于径向扩散率（λ）升高，表明髓鞘病理。 OA的持续时间较长还与轴突弥漫性（λ1）有关，在上纵筋膜和右额白质中最强，提示长期使用者存在轴突损伤。总之，这些发现表明，长期使用OA对神经元连接和功能具有广泛而多样的影响。

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