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首页> 外文期刊>Addiction biology >Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains
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Using monosodium glutamate to initiate ethanol self-administration in inbred mouse strains

机译：使用谷氨酸钠在近交小鼠品系中启动乙醇自我管理

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摘要

Voluntary oral ethanol consumption in rodents is generally limited by strong taste-aversion in these species. Historically, this has been overcome by combining ethanol with a sweetener, typically sucrose or saccharine, and then slowly 'fading' away the sweetener. While useful in most instances, this approach has not proven as successful for some inbred strains of mice (e.g. DBA/2J) despite consistent evidence in the literature that these same strains express strong conditioned place preference for intraperitoneal- or intragastric-administered ethanol. Importantly, DBA/2J mice express a polymorphism in a 'sweet' taste receptor subunit gene that reduces the potency of sweet substances in these mice. We hypothesized that the presence of this polymorphism might help explain the contrasting behavioral findings of weak voluntary oral ethanol consumption following sucrose-fade yet robust conditioned place preference for ethanol in this strain. To test this, we compared ethanol consumption initiated by either a 'traditional' sucrose-fade or a fade from an alternative tastant, monosodium glutamate (MSG). We found that in both C57BL/6J and DBA/2J mice, the MSG-fade produced robust increases in home cage ethanol consumption relative to the traditional sucrose-fade. This increased ethanol intake following MSG-fade was evident across a range of ethanol concentrations. Our findings suggest the potential utility of the MSG-fade to establish stable voluntary oral ethanol consumption in mice, particularly ethanol 'non-preferring' strains such as DBA/2J and lend additional support to the notion that ethanol consumption in DBA/2J mice is limited by pronounced taste aversion.
机译：啮齿类动物自愿口服乙醇的消耗通常受到这些物种强烈的厌恶口味的限制。从历史上看，已通过将乙醇与甜味剂（通常为蔗糖或糖精）混合，然后缓慢“淡化”甜味剂来克服这一问题。尽管在大多数情况下有用，但这种方法尚未被证明对某些自交系小鼠（例如DBA / 2J）是成功的，尽管在文献中有一致的证据表明这些相同的菌株对腹膜内或胃内施用的乙醇表现出强烈的条件性位置偏爱。重要的是，DBA / 2J小鼠在“甜味”味觉受体亚基基因中表达了一种多态性，从而降低了这些小鼠中甜味物质的功效。我们假设这种多态性的存在可能有助于解释在该菌株中蔗糖褪色后自愿口服乙醇消费量较弱但对乙醇的适应性条件偏好强烈的相反行为发现。为了测试这一点，我们比较了“传统”蔗糖褪色或替代味精味精（MSG）褪色引发的乙醇消耗。我们发现，在C57BL / 6J和DBA / 2J小鼠中，相对于传统的蔗糖衰落，MSG衰落产生的笼笼乙醇消耗量均大幅增加。在一系列乙醇浓度下，MSG衰减后乙醇摄入量的增加是显而易见的。我们的发现表明，MSG淡入淡出法可在小鼠中建立稳定的自愿口服乙醇消耗量，尤其是乙醇“非优先”品系（例如DBA / 2J），并为DBA / 2J小鼠消耗乙醇的观点提供了额外的支持。受明显的口感厌恶的限制。

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