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首页> 外文期刊>Addiction biology >Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice
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Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice

机译：巴氯芬和催产素对小鼠慢性心理应激后乙醇摄入增加的差异作用

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Chronic stress is known to enhance the susceptibility for addiction disorders including alcoholism. While these findings have been recapitulated in animal models, the majority of these studies have utilized non-social rather than social stress paradigms; the latter of which are believed to be more relevant to the human situation. Therefore, the major aim of this study was to investigate, if 14 days of chronic subordinate colony housing (CSC), a pre-clinically validated psychosocial stress paradigm relevant for human psychiatric and somatic disorders, enhances ethanol (EtOH) consumption in male mice. To assess this, we employed the well-established two-bottle free-choice paradigm where mice were given access to water and 2, 4, 6 and 8% EtOH solutions (with the concentrations increasing each fourth day) following termination of the stress procedure. After 14 days of CSC, stressed mice consumed significantly more EtOH at all concentrations tested and displayed increased EtOH preference at concentrations of 6 and 8%. This effect was not due to an altered taste preference in CSC mice as assessed by saccharine- and quinine-preference tests, but was accompanied by increased anxiety-related behavior. Systemic administration of baclofen (2.5 mg/kg) or oxytocin (OXT; 10 mg/kg) reduced the EtOH intake in single housed control (baclofen, OXT) and CSC (baclofen) mice, whereas intracerebroventricular OXT (0.5 μg/2 μl) was ineffective in both groups. Taken together, these results suggest that (i) chronic psychosocial stress enhances EtOH consumption, and (ii) baclofen and OXT differentially affect EtOH intake in mice.
机译：已知慢性应激会增强对包括酒精中毒在内的成瘾性疾病的敏感性。虽然这些发现已在动物模型中进行了概括，但大多数研究还是利用了非社会压力范式而非社会压力范式。后者被认为与人类状况更为相关。因此，本研究的主要目的是研究是否有14天的慢性下属殖民地住房（CSC）（一种经过临床验证的与人类精神病和躯体疾病有关的心理社会压力范例）是否能增加雄性小鼠的乙醇（EtOH）消耗量。为了评估这一点，我们采用了公认的两瓶自由选择范式，在应激程序终止后，小鼠可以接触水和2、4、6、8％的EtOH溶液（浓度每四天增加一次） 。 CSC 14天后，压力小鼠在所有测试浓度下均消耗更多的EtOH，并且在6％和8％的浓度下显示出更高的EtOH偏好性。这种作用不是由于糖精和奎宁偏爱试验所评估的CSC小鼠口味偏好的改变，而是伴随着焦虑相关行为的增加。全身施用巴氯芬（2.5 mg / kg）或催产素（OXT; 10 mg / kg）减少了单笼对照组（baclofen，OXT）和CSC（baclofen）小鼠的EtOH摄入量，而脑室内OXT（0.5μg/ 2μl）两组均无效。两者合计，这些结果表明（i）长期的社会心理压力会增加EtOH的消耗，并且（ii）巴氯芬和OXT会差异影响小鼠的EtOH摄入量。

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