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首页> 外文期刊>Addiction biology >Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat
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Pregabalin reduces cocaine self-administration and relapse to cocaine seeking in the rat

机译：普瑞巴林减少了可卡因的自我给药和大鼠中可卡因的寻找和复发

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Pregabalin (Lyrica?) is a structural analog of γ-aminobutyric acid (GABA) and is approved by the FDA for partial epilepsy, neuropathic pain and generalized anxiety disorders. Pregabalin also reduces excitatory neurotransmitter release and post-synaptic excitability. Recently, we demonstrated that pregabalin reduced alcohol intake and prevented relapse to the alcohol seeking elicited by stress or environmental stimuli associated with alcohol availability. Here, we sought to extend these findings by examining the effect of pregabalin on cocaine self-administration (0.25 mg/infusion) and on cocaine seeking elicited by both conditioned stimuli and stress, as generated by administration of yohimbine (1.25 mg/kg). The results showed that oral administration of pregabalin (0, 10 or 30 mg/kg) reduced self-administration of cocaine over an extended period (6 hours), whereas it did not modify self-administration of food. In cocaine reinstatement studies, pregabalin (10 and 30 mg/kg) abolished the cocaine seeking elicited by both the pharmacological stressor yohimbine and the cues predictive of cocaine availability. Overall, these results demonstrate that pregabalin may have potential in the treatment of some aspects of cocaine addiction.
机译：普瑞巴林（Lyrica？）是γ-氨基丁酸（GABA）的结构类似物，并已获得FDA批准用于部分癫痫，神经性疼痛和广泛性焦虑症。普瑞巴林还降低了兴奋性神经递质的释放和突触后的兴奋性。最近，我们证明了普瑞巴林减少了酒精的摄入，并防止了因与酒精供应相关的压力或环境刺激而引起的酒精寻回。在这里，我们试图通过检查普瑞巴林对可卡因自我给药（0.25 mg /输注）以及由育亨宾（1.25 mg / kg）产生的条件性刺激和压力引起的可卡因寻求的影响来扩展这些发现。结果表明，口服普瑞巴林（0、10或30 mg / kg）可以减少可卡因在较长时间（6小时）内的自我给药，而不会改变食品的自我给药。在可卡因恢复研究中，普瑞巴林（10和30 mg / kg）废除了由药理应激源育亨宾和可卡因可利用性预测所引起的可卡因寻求。总体而言，这些结果表明，普瑞巴林可能在治疗可卡因成瘾的某些方面具有潜力。

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