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首页> 外文期刊>Addiction >Usefulness of indirect alcohol biomarkers for predicting recidivism of drunk-driving among previously convicted drunk-driving offenders: Results from the Recidivism Of Alcohol-impaired Driving (ROAD) study
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Usefulness of indirect alcohol biomarkers for predicting recidivism of drunk-driving among previously convicted drunk-driving offenders: Results from the Recidivism Of Alcohol-impaired Driving (ROAD) study

机译：间接酒精生物标志物在预测先前定罪的醉酒驾车者中醉酒驾车再犯中的有用性：酒后驾车再犯研究（ROAD）的结果

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Aim: In several European countries, drivers under the influence (DUI), suspected of chronic alcohol abuse are referred for medical and psychological examination. This study (the ROAD study, or Recidivism Of Alcohol-impaired Driving) investigated the usefulness of indirect alcohol biomarkers for predicting drunk-driving recidivism in previously convicted drunk-driving offenders. Design, setting, participants and measurements: The ROAD study is a prospective study (2009-13) that was performed on 517 randomly selected drivers in Belgium. They were convicted for drunk-driving for which their licence was confiscated. The initial post-arrest blood samples were collected and analysed for percentage carbohydrate-deficient transferrin (%CDT), transaminsase activities [alanine amino transferase (ALT), aspartate amino transferase (AST)], gamma-glutamyltransferase (γGT) and red cell mean corpuscular volume (MCV). The observation time for each driver was 3 years and dynamic. Findings: A logistic regression analysis revealed that ln(%CDT) (P<0.001), ln(γGT) (P<0.01) and ln(ALT) (P<0.05) were the best biochemical predictors of recidivism of drunk-driving. The ROAD index (which includes ln(%CDT), ln(γGT), -ln(ALT) and the sex of the driver) was calculated and had a significantly higher area under the receiver operator characteristic curve (0.71) than the individual biomarkers for drunk-driving recidivism. Drivers with a high risk of recidivating (ROAD index≥25%; third tertile) could be distinguished from drivers with an intermediate risk (16%≤ROAD index<25%; second tertile; P<0.001) and a low recidivism risk (ROAD index<16%; first tertile; P<0.05). Conclusions: Of all routinely used indirect alcohol markers, percentage of carbohydrate-deficient transferrin is the major predictor of recidivism of drunk-driving. The association with gamma-glutamyltransferase, alanine amino transferase and the sex of the driver could have additional value for identifying drunk-drivers at intermediate risk of recidivism. Non-specific indirect alcohol markers, such as alanine amino transferase, gamma-glutamyltransferase, aspartate amino transferase and red cell mean corpuscular volume have minimal added value to % carbohydrate-deficient transferrin for distinguishing drunk drivers with a low or high risk of recidivism.
机译：目的：在几个欧洲国家，涉嫌受到慢性酒精滥用影响的驾驶员（DUI）被转诊接受医学和心理检查。这项研究（ROAD研究或“酒精中毒驾驶减免症”）调查了间接酒精生物标志物在预测先前定罪的酒后驾驶罪犯中的酒后驾驶再犯的有用性。设计，设置，参与者和度量：ROAD研究是一项前瞻性研究（2009-13年），对比利时的517名随机选择的驾驶员进行了研究。他们因醉酒驾驶被定罪，没收了驾照。收集最初的逮捕后血液样本，并分析其碳水化合物缺乏转铁蛋白（％CDT）的百分比，转氨酶活性[丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST）]，γ-谷氨酰转移酶（γGT）和红细胞平均值红细胞体积（MCV）。每个驾驶员的观察时间为3年且动态。研究结果：逻辑回归分析显示，ln（％CDT）（P <0.001），ln（γGT）（P <0.01）和ln（ALT）（P <0.05）是醉酒驾驶再犯的最佳生化指标。计算出ROAD指数（包括ln（％CDT），ln（γGT），-ln（ALT）和驾驶员性别），并且其接收者操作者特征曲线下的面积（0.71）比单个生物标记物高得多酒后驾车累犯。再次发生危险高的驾驶员（ROAD指数≥25％;三分位数）可以与中等危险（16％≤ROAD指数<25％;第二个三分位数; P <0.001）和较低的累犯风险（ROAD）相区别指数＜16％;第一三分位数; P ＜0.05）。结论：在所有常规使用的间接酒精标志物中，缺乏碳水化合物的转铁蛋白的百分比是醉酒驾驶再犯的主要预测指标。与γ-谷氨酰转移酶，丙氨酸氨基转移酶的关系以及驾驶员的性别对于识别处于再犯中间风险的醉酒驾驶员可能具有附加价值。非特异性间接酒精标记物，如丙氨酸氨基转移酶，γ-谷氨酰胺基转移酶，天冬氨酸氨基转移酶和红细胞平均红细胞体积，对缺乏碳水化合物的转铁蛋白百分比具有最小的增加价值，可用于区分具有低或高累犯风险的醉酒驾驶员。

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