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首页> 外文期刊>Molecular reproduction and development >Understanding follicle growth in vitro: Are we getting closer to obtaining mature oocytes from in vitro-grown follicles in human?
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Understanding follicle growth in vitro: Are we getting closer to obtaining mature oocytes from in vitro-grown follicles in human?

机译：了解体外卵泡生长：我们是否越来越接近人类在人体外生长的卵泡中获得成熟的卵母细胞？

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Obtaining and fertilizing mature oocytes from immature follicles that were grown outside the body has conceptually attracted scientists for centuries, with initial attempts first documented in the 19th century. Significant progress has been made since then, due in part to a better understanding of folliculogenesis and improved techniques of in vitro follicle growth. Indeed, in vitro growth is now considered a reasonable approach to preserve or restore fertility when immature follicles and their oocytes need to be grown and matured outside the body. Certain patients would benefit from in vitro follicle growth, particularly those who carry a risk of cancer re-seeding after grafting of frozen-thawed ovarian tissue or who are at the risk of premature ovarian failure due to several intrinsic ovarian defects and genetic mutations that lead to accelerated follicle atresia and early exhaustion of the ovarian reserve. This review provides an update on the current status of in vitro growth of preantral human follicles, from initial efforts to the most recent achievements.
机译：从概念性地吸引了世卫组织以外的未成熟卵泡，从概念上吸引了几个世纪的科学家，在19世纪首先记录了初步记录。从那时起，已经取得了重大进展，部分原因是更好地理解卵泡发生和体外卵泡生长的改进技术。实际上，在体外增长现在被认为是在不成熟的卵泡和它们的卵母细胞在体外生长和成熟时保持或恢复生育能力的合理方法。某些患者将受益于体外卵泡生长，特别是那些在覆盖卵巢卵巢组织或由于几种内在卵巢缺陷和潜在的卵巢突变导致的卵巢衰竭的风险之后携带癌症重新种子的风险。加速卵泡休息和卵巢储备的早期疲惫。该审查提供了关于预先努力的预先努力的最新成就的最新努力的现状。

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