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Hodgkin Lymphoma

机译:霍奇金淋巴瘤

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Hodgkin lymphoma (HL) is a very particular tumour for different reasons: it has a variable geographic, racial, and social epidemiology; it is related to Epstein Barr virus (EBV) infection, but the virus is rarely detectable in tumour cells; its multifactorial pathogenesis overlaps with other inflammatory and neoplastic processes, and it has different pathological features, resulting in different subtypes that may overlap with some NHLs. It has a good prognosis in most cases, but patients may develop reactive lymph node enlargements (LNe) over time, as well as relapses or secondary/iatrogenic neoplasms [1]. Despite these heterogeneities, HL has maintained its name, unicity, and classification over the years. HL-specific aspects affect corresponding fine-needle cytology (FNC) features and this should be kept in mind when dealing with HL. Clinical signs, if present, are nocturnal sweating, itch, fever, weakness, cough, or mediastinal syndrome, when mediastinum is involved. Regarding HL staging, the Cotswolds modification of the Ann Arbor Staging System [2] has maintained the 4 original clinical pathological stages.
机译:霍奇金淋巴瘤(HL)是一个非常特殊的肿瘤,因为不同的原因:它具有可变地理,种族和社会流行病学;它与Epstein Barr病毒(EBV)感染有关,但病毒在肿瘤细胞中很少可检测到;其多因素发病机制与其他炎症和肿瘤过程重叠,并且具有不同的病理特征,导致不同的亚型可以与一些NHL重叠。在大多数情况下,它具有良好的预后,但患者可能随着时间的推移而产生活性淋巴结增大(LNE),以及复发或次要/认可肿瘤[1]。尽管这些异质性,但多年来,HL保持了其名称,单性和分类。特定HL特异性方面影响相应的细针细胞学(FNC)特征,应在处理HL时保留这一点。临床症状,如果存在,夜间汗水,瘙痒,发热,弱点,咳嗽或纵隔综合征,当涉及时,患有亚氏菌素。关于HL分期,ANN Arbor Staging System的CotSwolds修改[2]保持了4个原始临床病理阶段。

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