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首页> 外文期刊>Medical Molecular Morphology >B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma
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B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma

机译：B细胞淋巴瘤，无法分类，其特征介于弥漫性大B细胞淋巴瘤和经典的霍奇金淋巴瘤之间，而无纵隔疾病：模仿结节性硬化症经典的霍奇金淋巴瘤

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摘要

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma (BCLu-DLBCL/CHL), also known as gray-zone lymphoma, has overlapping clinical and biological characteristics of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (CHL). These lymphomas are typically associated with mediastinal disease, and extranodal involvement is rare. In the present report, we describe a case of a 78-year-old woman with BCLu-DLBCL/CHL found to have extranodal lesions and no evidence of mediastinal disease. Although biopsy specimens were histologically similar to nodular sclerosis CHL, the tumor cells were positive for CD30 and mature B-cell markers, such as CD20, CD79a, PAX5, BOB.1, and OCT-2, but negative for CD15. Furthermore, the patient had extranodal lesions and an increased level of soluble IL-2 receptor. These findings are unusual in CHL. Therefore, we diagnosed the patient with BCLu-DLBCL/CHL. She received adriamycin, bleomycin, vincristine, and dacarba-zine therapy and exhibited partial response. Some cases without mediastinal disease, such as our case, have been reported; however, these cases are rare and further studies are required.
机译：B细胞淋巴瘤，无法分类，其特征介于弥漫性大B细胞淋巴瘤和经典霍奇金淋巴瘤（BCLu-DLBCL / CHL）之间，也称为灰区淋巴瘤，在弥散性大B细胞中具有重叠的临床和生物学特征淋巴瘤和经典霍奇金淋巴瘤（CHL）。这些淋巴瘤通常与纵隔疾病有关，结外累及很少见。在本报告中，我们描述了一个患有BCLu-DLBCL / CHL的78岁女性的病例，该女性被发现有结外病变且没有纵隔疾病的证据。尽管活检标本在组织学上与结节性硬化症CHL相似，但肿瘤细胞CD30和成熟的B细胞标志物（例如CD20，CD79a，PAX5，BOB.1和OCT-2）呈阳性，而CD15呈阴性。此外，患者有结外病变和可溶性IL-2受体水平升高。这些发现在CHL中是不寻常的。因此，我们诊断出患有BCLu-DLBCL / CHL的患者。她接受了阿霉素，博来霉素，长春新碱和达卡巴嗪治疗，并表现出部分反应。已经报告了一些没有纵隔疾病的病例，例如我们的病例。但是，这些情况很少见，需要进一步研究。

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  • 来源
    《Medical Molecular Morphology》 |2013年第3期|172-176|共5页
  • 作者

    Noriko Iwaki; Yasuharu Sato; Toshiro Kurokawa; Yoshinobu Maeda; Kyotaro Ohno; Mai Takeuchi; Katsuyoshi Takata; Yorihisa Orita; Shinji Nakao; Tadashi Yoshino;

  • 作者单位

    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,2-5-1 Shikata-cho, Okayama 700-8558, Japan Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;

    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,2-5-1 Shikata-cho, Okayama 700-8558, Japan;

    Department of Hematology, Toyama Red Cross Hospital,Toyama, Japan;

    Department of Pathology, Toyama Red Cross Hospital, Toyama,Japan;

    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,2-5-1 Shikata-cho, Okayama 700-8558, Japan;

    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,2-5-1 Shikata-cho, Okayama 700-8558, Japan;

    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,2-5-1 Shikata-cho, Okayama 700-8558, Japan;

    Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

    Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;

    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,2-5-1 Shikata-cho, Okayama 700-8558, Japan;

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  • 正文语种 eng
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  • 关键词

    Gray-zone lymphoma; Diffuse large B-cell lymphoma; Nodular sclerosis classical Hodgkin lymphoma; Immunohistochemistry;

    机译：灰区淋巴瘤;弥漫性大B细胞淋巴瘤;结节性硬化症经典霍奇金淋巴瘤;免疫组织化学;

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