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首页> 美国卫生研究院文献>Oncology Letters >Primary splenic B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report
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Primary splenic B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A case report

机译：原发性脾脏B细胞淋巴瘤无法分类特征介于弥漫性大B细胞淋巴瘤和经典霍奇金淋巴瘤之间：1例

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摘要

B-cell lymphoma (BCL), unclassifiable, with features intermediate between diffuse large BCL (DLBCL) and classical Hodgkin's lymphoma (CHL), is a novel entity to the World Health Organization classification system. These tumors are rare aggressive lymphomas that have a poor prognosis. The present study reports the case of a patient with one such lymphoma that occurred in the spleen, which expressed cluster of differentiation (CD)20, CD79α, melanoma associated antigen (mutated) 1, BCL6, CD15 and CD30. Polymerase chain reaction analysis demonstrated a clonal rearrangement of the genes coding for immunoglobulin heavy chains. The tumor cells demonstrated a negative reaction in the Epstein-Barr virus-encoded small RNA assay. Following the diagnosis of unclassifiable BCL, with intermediate features between DLBCL and CHL, the patient received 7 cycles of the CHOP regimen, and so far, has been in good general condition and tumor-free for 17 months.
机译：B细胞淋巴瘤（BCL）无法分类，其特征介于弥漫性大BCL（DLBCL）和经典霍奇金淋巴瘤（CHL）之间，是世界卫生组织分类系统的一个新颖实体。这些肿瘤是罕见的侵袭性淋巴瘤，预后较差。本研究报道了一名患有脾脏的淋巴瘤患者的病例，该淋巴瘤表达分化簇（CD）20，CD79α，黑色素瘤相关抗原（突变）1，BCL6，CD15和CD30。聚合酶链反应分析显示了编码免疫球蛋白重链的基因的克隆重排。在爱泼斯坦-巴尔病毒编码的小RNA分析中，肿瘤细胞显示出阴性反应。在诊断出无法分类的BCL并在DLBCL和CHL之间具有中间特征之后，该患者接受了7个周期的CHOP方案治疗，迄今为止，该患者处于良好的一般状态且无肿瘤17个月。

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