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首页> 外文期刊>Addiction biology >No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms.
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No association of alcohol dependence with SLC6A5 and SLC6A9 glycine transporter polymorphisms.

机译：酒精依赖与SLC6A5和SLC6A9甘氨酸转运蛋白多态性没有关联。

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摘要

To determine whether glycine transporter polymorphisms are associated with alcoholism, three genetic variants of SLC6A5 and two polymorphisms of SLC6A9 were genotyped in 463 German non-alcoholic controls and 644 German alcohol-dependent subjects. Association was investigated employing chi-square statistics and haplotype analysis. There was a significant association between the SLC6A5 polymorphism (rs1443547) and alcohol dependence as alcoholic individuals had a lower rate of AG-allele (chi(2) = 6.048, P = 0.049, d.f. = 2), which did not remain significant after correction for multiple testing. There was no association between SLC6A9 glycine transporter polymorphisms and alcohol dependence, and also none in haplotype analysis.
机译：为了确定甘氨酸转运蛋白多态性是否与酒精中毒有关，我们在463名德国非酒精性对照者和644名德国酒精依赖性受试者中对SLC6A5的三种遗传变异和SLC6A9的两种多态性进行了基因分型。协会采用卡方统计和单倍型分析进行了调查。 SLC6A5多态性（rs1443547）与酒精依赖之间存在显着相关性，因为酒精中毒个体的AG等位基因发生率较低（chi（2）= 6.048，P = 0.049，df = 2），校正后仍不显着用于多次测试。 SLC6A9甘氨酸转运蛋白多态性与酒精依赖性之间没有关联，在单倍型分析中也没有关联。

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