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首页> 外文期刊>Addiction biology >Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area.
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Electroacupuncture treatment reverses morphine-induced physiological changes in dopaminergic neurons within the ventral tegmental area.

机译：电针治疗可逆转吗啡引起的腹侧被盖区多巴胺能神经元的生理变化。

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摘要

Chronic morphine administration decreases the size of dopamine (DA) neurons in the ventral tegmental area (VTA). These transient morphological changes are accompanied by a reduced sensitivity of morphine-induced conditioned place preference (CPP) after chronic exposure to the drug. In this study we examined alterations in the firing rate of DAergic neurons by means of extracellular recording following chronic morphine exposure and applied 100 Hz electroacupuncture (EA) treatment to reverse the reduced firing rate of these neurons. In the first set of experiments we show that in rats, which received chronic morphine treatment for 14 days, a small dose of morphine was not able to induce a CPP response anymore. However, the sensitivity to morphine was reinstated by consecutive EA treatment for 10 days. The electrophysiological response of VTA DA neurons to morphine was markedly reduced in chronic morphine-treated rats compared to saline-treated controls. A substantial recovery of the reactivity of VTA DA neurons to morphine was observed in rats that received 100 Hz EA for 10 days. Our findings suggest that 100 Hz EA is a potential therapy for the treatment of opiate addiction by normalizing the activity of VTA DA neurons.
机译：长期服用吗啡可减少腹侧被盖区（VTA）中多巴胺（DA）神经元的大小。这些短暂的形态变化伴随着长期暴露于药物后吗啡诱导的条件性位置偏爱（CPP）的敏感性降低。在这项研究中，我们通过慢性吗啡暴露后通过细胞外记录检查了DAergic神经元放电速率的变化，并应用100 Hz电针（EA）处理以逆转这些神经元降低的放电速率。在第一组实验中，我们显示了在接受了14天慢性吗啡治疗的大鼠中，小剂量吗啡不再能够诱导CPP反应。但是，连续EA治疗10天恢复了对吗啡的敏感性。与盐水处理的对照组相比，慢性吗啡处理的大鼠中VTA DA神经元对吗啡的电生理反应明显降低。在接受100 Hz EA持续10天的大鼠中，观察到VTA DA神经元对吗啡的反应性已基本恢复。我们的发现表明，通过使VTA DA神经元的活性正常化，100 Hz EA是治疗阿片成瘾的潜在疗法。

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