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首页> 外文期刊>Addictive behaviors >Efficacy of a flexible quit date versus an a priori quit date approach to smoking cessation: a cross-study analysis.
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Efficacy of a flexible quit date versus an a priori quit date approach to smoking cessation: a cross-study analysis.

机译：灵活戒烟日期与先验戒烟日期方法对戒烟的功效：一项跨研究分析。

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Most treatment guidelines recommend that smokers should set a target quit date (TQD) at treatment onset because making a public commitment to quit on a given date should increase motivation. On the other hand, allowing smokers the flexibility to choose when to stop after starting treatment might allow smokers to better tailor their quit date and might improve the acceptability of treatment among smokers not willing to set a TQD. In a recent placebo-controlled study, we found varenicline effective when smokers were not required to set a quit date a priori; i.e., with a "flexible quit date" (FQD) approach. The current analysis compares the effect sizes and quit rates in this FQD study with those of nine prior varenicline randomized controlled trials (RCTs) that used a TQD approach. The odds ratio for varenicline versus placebo in the FQD study was the 4th highest of the 10 trials and the incidence of continuous abstinence for varenicline was 5th highest. These results suggest that a FQD approach can produce quit rates similar to a TQD approach. Cross-study comparisons can have hidden bias; thus, a RCT of fixed versus flexible quit dates would provide a more valid test. Also, a study of whether different subpopulations of smokers may be more interested in or especially benefit from, one or the other approach to quitting is indicated.
机译：大多数治疗指南建议吸烟者应在治疗开始时设定目标戒烟日期（TQD），因为在特定日期公开承诺戒烟会增加动机。另一方面，允许吸烟者在开始治疗后灵活选择何时停止吸烟，可以使吸烟者更好地调整戒烟日期，并可能提高不愿意设定TQD的吸烟者的接受性。在最近的安慰剂对照研究中，当不需要吸烟者事先确定戒烟日期时，伐尼克兰有效。即采用“灵活退出日期”（FQD）方法。当前的分析比较了该FQD研究与使用TQD方法进行的9项先前缬草碱随机对照试验（RCT）的疗效大小和戒烟率。 FQD研究中伐尼克兰与安慰剂的比值比是10个试验中的第4高，连续禁欲发生伐尼克兰的发生率是第5高。这些结果表明，FQD方法可以产生与TQD方法相似的退出率。跨研究比较可能具有隐藏的偏见。因此，固定和灵活退出日期的RCT将提供更有效的测试。而且，指示了关于吸烟者的不同亚群是否可能对一种或另一种戒烟方法更感兴趣或尤其从中受益的研究。

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