...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanotoxicology >Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3
【24h】

Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3

机译：大鼠肿瘤内滴注后二氧化钛纳米粒子的定量发作性：第3部分

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The biokinetics of a size-selected fraction (70nm median size) of commercially available and V-48-radiolabeled [V-48]TiO2 nanoparticles has been investigated in healthy adult female Wistar-Kyoto rats at retention time-points of 1h, 4h, 24h, 7d and 28d after intratracheal instillation of a single dose of an aqueous [V-48]TiO2-nanoparticle suspension. A completely balanced quantitative biodistribution in all organs and tissues was obtained by applying typical [V-48]TiO2-nanoparticle doses in the range of 40-240 mu g.kg(-1) bodyweight and making use of the high sensitivity of the radiotracer technique. The [V-48]TiO2-nanoparticle content was corrected for residual blood retained in organs and tissues after exsanguination and for V-48-ions not bound to TiO2-nanoparticles. About 4% of the initial peripheral lung dose passed through the air-blood-barrier after 1h and were retained mainly in the carcass (4%); 0.3% after 28d. Highest organ fractions of [V-48]TiO2-nanoparticles present in liver and kidneys remained constant (0.03%). [V-48]TiO2-nanoparticles which entered across the gut epithelium following fast and long-term clearance from the lungs via larynx increased from 5 to 20% of all translocated/absorbed [V-48]TiO2-nanoparticles. This contribution may account for 1/5 of the nanoparticle retention in some organs. After normalizing the fractions of retained [V-48]TiO2-nanoparticles to the fraction that reached systemic circulation, the biodistribution was compared with the biodistributions determined after IV-injection (Part 1) and gavage (GAV) (Part 2). The biokinetics patterns after IT-instillation and GAV were similar but both were distinctly different from the pattern after intravenous injection disproving the latter to be a suitable surrogate of the former applications. Considering that chronic occupational inhalation of relatively biopersistent TiO2-particles (including nanoparticles) and accumulation in secondary organs may pose long-term health risks, this issue should be scrutinized more comprehensively.
机译：在保留时间点为1H，4h，4h，4h，4h，在腹腔内滴注单剂量的[V-48] TiO2-纳米颗粒悬浮液后24h，7d和28d。通过施加40-240μmG.kg（-1）体重的范围，使用典型的[V-48] TiO2-纳米颗粒剂量并利用放射性机构的高灵敏度来获得所有器官和组织中的完全平衡的定量生物分布。技术。校正[V-48] TiO2-纳米颗粒含量校正在放血后残留的血液中保留的残留血液和未与TiO2-纳米颗粒结合的V-48-离子。大约4％的初始外周肺剂量通过1小时后通过空气障碍，并主要在胎体中保留（4％）; 28D后0.3％。肝脏和肾脏存在于肝脏和肾脏中的最高器官级数仍然是恒定的（0.03％）。 [V-48]通过喉部肺部快速和长期间隙进入肠道上皮的TiO2-纳米颗粒从所有易位/吸收的[V-48] TiO2-纳米颗粒的5-20％增加。这种贡献可能占一些器官中的1/5纳米粒子保留。将保留[V-48] TiO2-纳米颗粒的级分归一化为达到全身循环的级分之后，将生物分布与静脉注射（第1部分）和Gavage（Gav）（第2部分）测定的生物分布进行比较。它在IT-灌输和GAV之后的生物机构模式类似，但在静脉注射后，均与图案不同的模式不同，使后者成为前一种应用的合适替代品。考虑到慢性职业吸入相对生物的TiO2-颗粒（包括纳米颗粒）和中学器官积累可能会造成长期的健康风险，应更全面地审查这个问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号