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The mediating role of depression in the relationship between anxiety sensitivity and alcohol dependence

机译：抑郁在焦虑敏感性和酒精依赖关系中的中介作用

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Background: Many studies have reported that Anxiety Sensitivity (AS) is positively associated with alcohol use or other alcohol-related variables. More recent mediator and moderator models have shown promise in elucidating mechanisms within this relationship; the literature to date suggests that the relationship between AS and alcohol is likely mediated by problematic coping motives. However, few studies have considered the effects of depression within the AS-alcohol use relationship, despite a strong body of evidence linking AS to subsequent depression and depression to subsequent alcohol use problems, independently. Therefore, the current study assessed depression as a potential mediator of this relationship. Method: Participants were 418 sequential admissions to a substance abuse treatment facility. A mediation analysis using bootstrapping was utilized in order to estimate indirect effects of AS on alcohol dependence through depression. Results: Results reveal an indirect effect suggesting that the effects of anxiety sensitivity on alcohol dependence are mediated by symptoms of depression. More specifically, the effects of AS total score and AS somatic sensations on alcohol dependence were mediated by symptoms of depression. Lastly, a dual mediator model demonstrated that both depression and problematic coping uniquely mediate the relationship between AS and alcohol dependence. Conclusions: While preliminary in nature, the current study provides evidence supporting the hypothesis that depression is an important factor to consider when examining the relationship between AS and alcohol dependence.
机译：背景：许多研究报道，焦虑敏感性（AS）与饮酒或其他与酒精有关的变量呈正相关。最近的调解人和主持人模型在阐明这种关系中的机制方面显示出了希望。迄今为止的文献表明，AS和酒精之间的关系可能是由有问题的应对动机所介导的。然而，尽管有大量的证据独立地将AS与随后的抑郁症相关联以及将抑郁与随后的酒精使用问题相关联，但很少有研究考虑过抑郁症在AS-酒精使用关系中的影响。因此，本研究评估抑郁是这种关系的潜在介导者。方法：参与者连续418次进入滥用药物治疗设施。为了估计AS通过抑郁症对酒精依赖的间接影响，使用了自举法进行的调解分析。结果：结果显示了间接影响，表明焦虑敏感性对酒精依赖的影响是由抑郁症状介导的。更具体地说，AS总分和AS躯体感觉对酒精依赖的影响是由抑郁症状介导的。最后，双重介体模型证明抑郁症和有问题的应对方式均能独特地介导AS与酒精依赖之间的关系。结论：虽然是初步研究，但本研究提供了支持以下假设的证据：抑郁是检查AS与酒精依赖之间关系时要考虑的重要因素。

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