Acid-sensing ion channels in pain and disease.

John A Wemmie; Rebecca J Taugher; Collin J Kreple

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Acid-sensing ion channels in pain and disease.

机译：酸性和疾病中的酸感测离子通道。

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Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the past two decades. Significant progress has been made in understanding the structure and function of ASICs at the molecular level. Studies aimed at clarifying their physiological importance have suggested roles for ASICs in pain, neurological and psychiatric disease. This Review highlights recent findings linking these channels to physiology and disease. In addition, it discusses some of the implications for therapy and points out questions that remain unanswered.

机译：为什么神经元感测细胞外酸？在很大程度上，该问题在过去二十年中推动了CNS中CNS和周围神经系统的酸感测离子通道（ASIC）的调查。在理解分子水平的结构和功能方面取得了重大进展。旨在澄清其生理重要性的研究表明疼痛，神经和精神病疾病中的睾丸作用。此综述亮点最近的调查结果将这些渠道与生理和疾病联系起来。此外，它还讨论了对治疗的一些影响，并指出了仍未答复的问题。

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《Nature reviews neuroscience》 |2013年第7期|共11页
作者
John A Wemmie; Rebecca J Taugher; Collin J Kreple;
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Psychiatry Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa City Iowa;

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正文语种 eng
中图分类神经生理学;
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1. Acid-sensing ion channels in pain and disease. [J] . John A Wemmie, Rebecca J Taugher, Collin J Kreple Nature reviews neuroscience . 2013,第7期

机译：在疼痛和疾病中的酸敏感离子通道。
2. ACID-SENSING ION CHANNELS IN THE PAIN PATHWAY OR HOW ANIMAL TOXINS CAN HELP TO UNDERSTAND PAIN [J] . Lingueglia Eric Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2018,第期

机译：酸性途径中的酸感测离子通道或动物毒素如何有助于理解疼痛
3. Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain [J] . Clinical and experimental pharmacology & physiology . 2016,第2期

机译：三叉神经节神经元中支配口面区域的酸敏感离子通道有助于口面炎性疼痛
4. Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation [C] . Huaiyu Yang, Ye Yu, Wei-Guang Li, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：酸敏感离子通道1（ASIC1）上的构象采样：对对称构象的影响
5. Acid-sensing ion channels: Regulation and physiologic function . [D] . Cho, Jun-Hyeong. 2008

机译：酸敏感离子通道：调节和生理功能。
6. Acid-Sensing Ion Channels in Postoperative Pain [O] . Emmanuel Deval, Jacques Noël, Xavier Gasull, 2011

机译：术后疼痛中的酸敏感离子通道
7. Acid-sensing channels in human bladder: expression, function and alterations during bladder pain syndrome [O] . Sánchez-Freire, V, Blanchard, M G, Burkhard, F C, 2011

机译：人膀胱中的酸敏感通道：膀胱疼痛综合征期间的表达，功能和改变

Acid-sensing ion channels in pain and disease.

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