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Transient CNS responses to repeated binge ethanol treatment

机译：瞬态中枢神经系统对反复暴饮乙醇处理的反应

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The effects of ethanol (EtOH) on in vivo magnetic resonance (MR)-detectable brain measures across repeated exposures have not previously been reported. Of 28 rats weighing 340.66 +/- 21.93g at baseline, 15 were assigned to an EtOH group and 13 to a control group. Animals were exposed to five cycles of 4days of intragastric (EtOH or dextrose) treatment and 10days of recovery. Rats in both groups had structural MR imaging and whole-brain MR spectroscopy (MRS) scans at baseline, immediately following each binge period and after each recovery period (total=11 scans per rat). Blood alcohol level at each of the five binge periods was similar to 300mg/dl. Blood drawn at the end of the experiment did not show group differences for thiamine or its phosphate derivatives. Postmortem liver histopathology provided no evidence for hepatic steatosis, alcoholic hepatitis or alcoholic cirrhosis. Cerebrospinal fluid volumes of the lateral ventricles and cisterns showed enlargement with each binge EtOH exposure but recovery with each abstinence period. Similarly, changes in MRS metabolite levels were transient: levels of N-acetylaspartate and total creatine decreased, while those of choline-containing compounds and the combined resonance from glutamate and glutamine increased with each binge EtOH exposure cycle and then recovered during each abstinence period. Changes in response to EtOH were in expected directions based on previous single-binge EtOH exposure experiments, but the current MR findings do not provide support for accruing changes with repeated binge EtOH exposure.
机译：以前没有报道过反复暴露中乙醇（EtOH）对体内磁共振（MR）可检测的大脑测量的影响。在基线时体重为340.66 +/- 21.93g的28只大鼠中，有15只被划入EtOH组，而13只被划入对照组。使动物暴露于胃内（EtOH或葡萄糖）治疗4天和恢复10天的五个周期。两组大鼠在基线时，紧随每个暴饮暴食期之后和每个恢复期之后均进行了结构性MR成像和全脑MR光谱（MRS）扫描（每只大鼠总共11次扫描）。在五个暴饮暴食期的每个阶段，血液酒精含量均接近300mg / dl。实验结束时抽取的血液未显示硫胺素或其磷酸盐衍生物的组别差异。死后的肝脏组织病理学未提供肝脂肪变性，酒精性肝炎或酒精性肝硬化的证据。每次暴饮EtOH时，侧脑室和水箱的脑脊髓液体积会增大，但在每个禁欲期都会恢复。同样，MRS代谢产物水平的变化是短暂的：N-乙酰天门冬氨酸和总肌酸水平下降，而含胆碱化合物的水平以及谷氨酸和谷氨酰胺的组合共振随每次暴饮暴食EtOH暴露周期而增加，然后在每个禁欲期恢复。根据以前的单次EtOH暴露实验，对EtOH的响应变化在预期的方向上，但是当前的MR发现并不能为重复暴饮EtOH暴露产生的变化提供支持。

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