Pathogenesis of parathyroid dysfunction in end-stage renal disease.

Silver J

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Pathogenesis of parathyroid dysfunction in end-stage renal disease.

机译：终末期肾脏疾病甲状旁腺功能不全的发病机制。

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The parathyroid functions to maintain normal calcium and phosphate homeostasis and is cenral to normal bone physiology. In end-stage renal disease (ESRD), there is a failure of these normal homeostatic mechanisms with the frequent development of secondary hyperparathyroidism, which contributes to the pathogenesis of renal bone disease. The phosphate retention of ESRD, together with the reduced serum calcium and 1,25-dihydroxycholecalciferol vitamin D(3) (1,25[OH](2)D(3)) concentrations are the known factors that determine the progression to secondary hyperparathyroidism. 1,25(OH)(2)D(3) markedly decreases parathyroid hormone (PTH) gene transcription, whereas the effects of calcium and phosphate are on PTH mRNA stability, PTH secretion, and parathyroid cell proliferation. The mechanisms of these effects are discussed in this review.

机译：甲状旁腺的功能是维持正常的钙和磷稳态，并以正常的骨生理为中心。在终末期肾病（ESRD）中，这些正常的体内平衡机制失败，继发性甲状旁腺功能亢进症的频繁发生，导致肾骨病的发病机理。 ESRD的磷酸盐保留，降低的血清钙和1,25-二羟基胆钙化固醇维生素D（3）（1,25 [OH]（2）D（3））浓度是决定继发甲状旁腺功能亢进发展的已知因素。 1,25（OH）（2）D（3）显着降低甲状旁腺激素（PTH）基因的转录，而钙和磷酸盐对PTH mRNA稳定性，PTH分泌和甲状旁腺细胞增殖的影响。这些影响的机制在本综述中进行了讨论。

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《Advances in renal replacement therapy》 |2002年第3期|共9页
作者
Silver J;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Parathyroid gland; Pathogenesis; Parathyroid hormone measurement; inorganic phosphate;

机译：甲状旁腺发病机制甲状旁腺激素测定无机磷酸盐;

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1. Pathogenesis of parathyroid dysfunction in end-stage renal disease. [J] . Silver J Advances in renal replacement therapy . 2002,第3期

机译：终末期肾脏疾病甲状旁腺功能不全的发病机制。
2. Improved parathyroid hormone control by cinacalcet is associated with reduction in darbepoetin requirement in patients with end-stage renal disease. [J] . Battistella M, Richardson RM, Bargman JM, Clinical nephrology . 2011,第2期

机译：西那卡塞特改善甲状旁腺激素的控制与终末期肾脏疾病患者减少darbepoetin的需求有关。
3. Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal disease. [J] . Wolf M, Thadhani R Seminars in dialysis . 2005,第4期

机译：除了矿物质和甲状旁腺激素：活性维生素D在终末期肾脏疾病中的作用。
4. Pathogenesis and Management of Vascular Calcification in Patients with End-Stage Renal Disease [C] . Tetsuya Ogawa, Kosaku Nitta Nihon To?seki Igakkai., Gakujutsu Shu?kai So?kai . 2018

机译：患有终末期肾病患者血管钙化的发病机制与管理
5. Examination of the influence of behavioral, normative and control beliefs on the adherence to a prescribed renal diet among elderly populations with chronic to end-stage renal disease. [D] . Cummings, Alicia Linda. 2009

机译：在慢性至终末期肾脏疾病的老年人群中，研究行为，规范和控制信念对遵守处方肾脏饮食的影响。
6. Perrone RD Mouksassi M-S Romero K et al. Total kidney volume is a prognostic biomarker of renal function decline and progression to end-stage renal disease in patients with autosomal dominant polycystic kidney disease. Kidney Int Rep. 2017;2:442–450 [O] . 2018

机译：Perrone RDMouksassi M-SRomero K等。总肾脏体积是常染色体显性遗传性多囊肾患者肾功能下降和进展为终末期肾脏疾病的预后生物标志物。肾脏国际代表； 2017年； 2：442–450
7. Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease. [O] . Maurits S Buiten, Mihály K de Bie, Joris I Rotmans, 2015

机译：血清心肌肌钙蛋白-I优于肌钙蛋白-T作为临床稳定的终末期肾病患者左心室功能障碍的标志物。

Pathogenesis of parathyroid dysfunction in end-stage renal disease.

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