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首页> 外文期刊>Nephrology. >Baseline characteristics of the autosomal‐dominant polycystic kidney disease sub‐cohort of the KoreaN cohort study for outcomes in patients with chronic kidney disease
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Baseline characteristics of the autosomal‐dominant polycystic kidney disease sub‐cohort of the KoreaN cohort study for outcomes in patients with chronic kidney disease

机译：慢性肾疾病患者核队列肾脏研究核心队列研究的基线特征

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ABSTRACT Aim The aim of this study was to describe the baseline characteristics of autosomal‐dominant polycystic kidney disease (ADPKD) in a cohort of Korean patients with chronic kidney disease (CKD). Methods From April 2011 to February 2016, patients with CKD stage 1–5 (pre‐dialysis) were enrolled as an ADPKD sub‐cohort of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease. Baseline characteristics, the correlation of kidney and liver volume and kidney function and the factors associated with kidney function were analysed. Results A total of 364 ADPKD patients with a mean estimated glomerular filtration rate (eGFR) of 68.1 ± 33.3 mL/min per 1.73 m 2 (50.5% male with a mean age of 47.0 ± 10.6 years) were enrolled from nine hospitals in Korea. Initially, 55.8% of the patients were asymptomatic, and pain was the most common symptom (12.9%); 87.6 and 77.5% of the patients had hypertension and hepatic cysts, respectively. The height‐adjusted total kidney volumes (htTKV) were higher in male patients than in female patients. In contrast, the height‐adjusted total liver volumes were higher in female patients than in male patients. The decrease rate of eGFR depending on Log(htTKV) was larger in the group aged between 41 and 50 years than the other age groups. Older age, a higher 24‐h urine protein excretion, larger htTKV and hyperuricemia were independently associated with lower eGFR, whereas using febuxostat was independently associated with higher eGFR. Conclusion This sub‐cohort will provide clinical characteristics and outcomes of Korean ADPKD patients, which can be compared with those of other previous cohorts. We have identified factors associated with advanced‐stage CKD in Korean patients with ADPKD.
机译：摘要旨在本研究的目的是描述韩国慢性肾病（CKD）队列核心核心群体的常染色体显性多囊肾病（ADPKD）的基线特征。方法方法从2011年4月到2016年2月，CKD第1-5阶段（透析前）的患者被纳入韩国队列患者慢性肾脏疾病患者的adpkd子队员。分析了基线特征，分析了肾脏和肝脏体积和肾功能的相关性以及与肾功能相关的因素。结果总共364例患有68.1±33.3ml / min的平均估计肾小球过滤速率（EGFR）的患者每1.73 m 2（50.5％的男性，平均年龄为47.0±10.6岁）。最初，55.8％的患者无症状，疼痛是最常见的症状（12.9％）; 87.6和77.5％的患者分别具有高血压和肝囊肿。男性患者的高度调整的总肾脏体积（HTTKV）高于女性患者。相比之下，女性患者的高度调整后的总肝体积高于男性患者。根据对数（HTTKV）的EGFR减少率在比其他年龄组的41至50岁之间的组更大。年龄较大的24小时尿蛋白排泄，较大的HTTKV和高尿酸血症与低EGFR独立相关，而使用Febuxostat与更高的EGFR独立相关。结论该亚队列将提供韩国ADPKD患者的临床特征和结果，可以与其他以前的队列的患者进行比较。我们已经确定了与韩国患者ADPKD患者的高级CKD相关的因素。

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