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Three-dimensional finite element model to study calcium distribution in oocytes

机译：三维有限元模型研究卵母细胞中钙分布

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摘要

Calcium is the most universal second messenger in cells and plays an important role in initiation, sustenance and termination of various activities in cells required for maintaining the structure and function of the cell. Calcium signal at fertilization is necessary for egg activation and exhibits specialized spatial and temporal dynamics. The specific calcium concentration distribution patterns in oocytes required for various activities such as egg fertilization and maturation are not well understood. In this paper, a three-dimensional finite element model is proposed to study the spatio-temporal calcium distribution in oocyte. The parameters such as buffers, SERCA pump, RyR calcium channel, point source and line source of calcium are incorporated in the model. The appropriate initial and boundary conditions have been framed on the basis of physical condition of the problem. A program is developed in MATLAB for simulation. The results have been used to study the effect of source geometry, RyR calcium channel, SERCA pump and buffers on cytosolic calcium concentration distribution in oocyte.
机译：钙是细胞中最普遍的第二个信使，并在维持细胞结构和功能所需的细胞中起始，寄托和终止的重要作用。受精的钙信号是卵激活并展示专门的空间和时间动态。各种活动所需的卵母细胞中的特定钙浓度分布模式并不充分理解。本文提出了一种三维有限元模型，用于研究卵母细胞中的时空钙分布。诸如缓冲器，Serca泵，Ryr钙通道，点源和线源的参数结合在模型中。在问题的身体状况的基础上已经构成了适当的初始和边界条件。在MATLAB中开发了一个程序进行仿真。结果已被用于研究源几何，RγR钙通道，Serca泵和缓冲对卵母细胞胞质钙浓度分布的影响。

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