Determining superior first-line therapy in metastatic bladder cancer

Apolo Andrea B.

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Determining superior first-line therapy in metastatic bladder cancer

机译：确定转移性膀胱癌中的优质一线疗法

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The ideal first-line treatment of cisplatin-ineligible patients with metastatic urothelial carcinoma (mUC) remains unknown pending results of randomized trials. Although mUC tumours are sensitive to chemotherapy, response durations are short. A new retrospective study provides data on the effectiveness of first-line PD-1/PD-L1 inhibitors compared with carboplatin-based chemotherapy in this setting.

机译：直铂型尿道癌（MUC）患者的理想一线治疗仍然是随机试验的未知结果。虽然MUC肿瘤对化疗敏感，但响应持续时间短。新的回顾性研究提供了与本次设置的基于卡铂的化疗相比的一线PD-1 / PD-L1抑制剂有效性的数据。

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《Nature reviews. Urology》 |2019年第12期|共2页
作者
Apolo Andrea B.;
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NCI Genitourinary Malignancies Branch Ctr Canc Res NIH Bethesda MD 20892 USA;

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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Determining superior first-line therapy in metastatic bladder cancer [J] . Apolo Andrea B. Nature reviews. Urology . 2019,第12期

机译：确定转移性膀胱癌中的优质一线疗法
2. Comparison of cetuximab to bevacizumab as the first-line bio-chemotherapy for patients with metastatic colorectal cancer: Superior progression-free survival is restricted to patients with measurable tumors and objective tumor response-a retrospective study [J] . Yang Yuan-Hao, Lin Jen-Kou, Chen Wei-Shone, Journal of Cancer Research and Clinical Oncology . 2014,第11期

机译：西妥昔单抗与贝伐单抗作为转移性结直肠癌患者一线生物化学疗法的比较：回顾性研究显示，无进展生存率仅限于可测量肿瘤和客观肿瘤反应的患者
3. Re: Phase III, Double-Blind, Randomized Trial that Compared Maintenance Lapatinib versus Placebo after First-Line Chemotherapy in Patients with Human Epidermal Growth Factor Receptor 1/2-Positive Metastatic Bladder Cancer Editorial Comment [J] . Chang Sam S. The Journal of Urology . 2018,第4期

机译：Re：III期，双盲，随机试验，在人表皮生长因子受体1/2阳性转移性膀胱癌患者中比较了Lapatinib对安慰剂的维护rapatinib与安慰剂编辑评论
4. Is High-Dose Chemotherapy Plus Stem-Cell Transplant the Standard Treatment for Patients Failing First-Line Chemotherapy for Metastatic Germ Cell Tumor? [C] . Christian Kollmannsberger, Lawrence Einhorn, Craig Nichols Genitourinary Cancers Symposium. . 2014

机译：高剂量化疗加干细胞移植对转移细胞肿瘤的一线化疗失败的患者的标准治疗吗？
5. The role of CD24 in human bladder cancer tumorigenesis and metastatic progression. [D] . Overdevest, Jonathan Brett. 2010

机译：CD24在人类膀胱癌的发生和转移过程中的作用。
6. Hyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report [O] . Shiyu Mao, Junfeng Zhang, Yadong Guo, 2019

机译：一线顺铂化疗后复发转移性尿路上皮膀胱癌患者抗程序性细胞死亡配体-1治疗后过度进展：病例报告
7. PCN339 - SPEAR-BLADDER (STUDY INFORMING TREATMENT PATHWAY DECISION IN BLADDER CANCER): TIMING OF TREATMENT FOLLOWING FIRST-LINE THERAPY IN PATIENTS WITH LOCALLY ADVANCED AND METASTATIC UROTHELIAL CANCER IN THE COMMUNITY ONCOLOGY SETTING IN THE UNITED STATES [O] . G. Doshi, A. Bhanegaonkar, M. Bharmal, 2018

机译：PCN339 - 矛膀胱（关于膀胱癌的治疗途径决定的研究）：在美国社区肿瘤学患者患者患者中的一线治疗后治疗时间

Determining superior first-line therapy in metastatic bladder cancer

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